Relative paucity of genes causing inviability in hybrids between Drosophila melanogaster and D. simulans.
Relative paucity of genes causing inviability in hybrids between Drosophila melanogaster and D. simulans.
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导致果蝇和模拟果蝇杂交种无法生存的基因相对较少。
DOI：
10.1093/genetics/150.3.1091
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发表时间：
1998
期刊：
影响因子：
3.3
通讯作者：
Rooney,P
中科院分区：
文献类型：
--
作者：
Coyne,JA;Simeonidis,S;Rooney,P
利用黑腹果蝇的缺陷，我们在姐妹种D中寻找基因组区域。在杂交遗传背景下半合子时可能导致致命性的simulans。这种基因型允许来自一个物种的半合子基因与来自其他物种的杂合子基因相互作用，并且可能对应于导致Halfman规则的基因型类型，该观察结果表明，如果物种杂交中只有一种性别是不育的或不能存活的，那么它几乎总是异配子性别。一项调查显示，大约50%的D。simulans基因组（114个染色体区域）显示只有4个区域引起杂种致死，5个区域引起杂种生存力的严重降低。然而，所有这些基因型的生活力至少部分恢复饲养杂交种在较低的温度或使用不同的遗传背景，从D。simulans。因此，我们没有检测到D。simulans染色体区域引起无条件的杂种致死性，尽管几个区域在大多数测试温度和遗传背景下显示出有害。相对缺乏的“不育基因”支持的想法，建议在其他物种的工作，即密切相关的物种之间的杂种不育可能是由相对较少的基因之间的相互作用，而杂种不育可能涉及更多的基因座。
Using deficiencies from Drosophila melanogaster, we looked for genomic regions in the sister species D. simulans that could cause lethality when hemizygous on a hybrid genetic background. Such genotypes allow hemizygous genes from one species to interact with heterozygous genes from other species and may correspond to the kinds of genotypes causing Haldane’s rule, the observation that if only one gender is sterile or inviable in species hybrids, it is nearly always the heterogametic sex. A survey of roughly 50% of the D. simulans genome (114 chromosome regions) revealed only four regions causing hybrid lethality and five causing severe reductions in hybrid viability. However, the viability of all of these genotypes was at least partially restored by rearing hybrids at lower temperature or using different genetic backgrounds from D. simulans. We therefore detected no D. simulans chromosome regions causing unconditional hybrid lethality, although several regions were shown to be deleterious under most tested temperatures and genetic backgrounds. The relative paucity of “inviability genes” supports the idea, suggested by work on other species, that hybrid inviability between closely related species might be caused by interactions among relatively few genes, while hybrid sterility may involve many more loci.