Non-coding RNAs in cardiac regeneration.
Non-coding RNAs in cardiac regeneration.
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非编码RNA在心脏再生中的作用
DOI：
10.18632/oncotarget.6073
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发表时间：
2015-12-15
期刊：
影响因子：
--
通讯作者：
Li X
中科院分区：
文献类型：
--
作者：
Tao L;Bei Y;Zhou Y;Xiao J;Li X
开发可以增强心肌细胞再生能力的新治疗策略具有重要的临床意义。尽管有希望，但由于成年哺乳动物心脏的再生能力较弱，促进心脏再生的方法取得的成功有限。非编码RNA（ncRNA），包括微小RNA（miRNA、miR）和长非编码RNA（lncRNA），是不具有蛋白质编码功能的功能性RNA分子，据报道参与心脏再生和修复。根据目前的再生策略，ncRNA的调节作用可分为以下几类：心脏增殖、心脏分化、心脏存活和心脏重编程。据报道，miR-590、miR-199a、miR-17-92 簇、miR302-367 簇和 miR-222 可促进心肌细胞增殖，而 miR-1 和 miR-133 可抑制心肌细胞增殖。 miR-499和miR-1促进心脏祖细胞分化为心肌细胞，而miR-133和H19则抑制这一过程。 miR-21、miR-24、miR-221、miR-199a 和 miR-155 可改善心脏存活率，而 miR-34a、miR-1 和 miR-320 则表现出相反的作用。 miR-1、miR-133、miR-208 和 miR-499 能够将成纤维细胞重编程为心肌细胞样细胞，而 miR-284、miR-302、miR-93、miR-106b 和 lncRNA-ST8SIA3 能够增强心脏重编程。探索基于非编码RNA的方法来增强心脏再生将有助于设计针对心血管疾病的新的有效疗法。
Developing new therapeutic strategies which could enhance cardiomyocyte regenerative capacity is of significant clinical importance. Though promising, methods to promote cardiac regeneration have had limited success due to the weak regenerative capacity of the adult mammalian heart. Non-coding RNAs (ncRNAs), including microRNAs (miRNAs, miRs) and long non-coding RNAs (lncRNAs), are functional RNA molecules without a protein coding function that have been reported to engage in cardiac regeneration and repair. In light of current regenerative strategies, the regulatory effects of ncRNAs can be categorized as follows: cardiac proliferation, cardiac differentiation, cardiac survival and cardiac reprogramming. miR-590, miR-199a, miR-17-92 cluster, miR302-367 cluster and miR-222 have been reported to promote cardiomyocyte proliferation while miR-1 and miR-133 suppress that. miR-499 and miR-1 promote the differentiation of cardiac progenitors into cardiomyocyte while miR-133 and H19 inhibit that. miR-21, miR-24, miR-221, miR-199a and miR-155 improve cardiac survival while miR-34a, miR-1 and miR-320 exhibit opposite effects. miR-1, miR-133, miR-208 and miR-499 are capable of reprogramming fibroblasts to cardiomyocyte-like cells and miR-284, miR-302, miR-93, miR-106b and lncRNA-ST8SIA3 are able to enhace cardiac reprogramming. Exploring non-coding RNA-based methods to enhance cardiac regeneration would be instrumental for devising new effective therapies against cardiovascular diseases.