Evidence of genetic regulation of fetal longitudinal growth
Evidence of genetic regulation of fetal longitudinal growth
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DOI：
10.1016/j.earlhumdev.2005.06.003
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发表时间：
2005-10-01
影响因子：
2.5
通讯作者：
Hattersley, AT
中科院分区：
文献类型：
--
作者：
Knight, B;Shields, BM;Hattersley, AT
背景：遗传和环境因素是胎儿生长发育的重要决定因素，但父性因素对胎儿生长发育影响的研究较少。目的：研究父亲的人体测量学对出生时子女的详细测量的影响。设计：一项前瞻性队列研究，包括孕28周的母亲和父亲的生化和人体测量学，以及出生后24小时内儿童的详细人体测量学。研究对象：从英国埃克塞特中心招募的567名白人独生子女，非糖尿病，足月妊娠。结果：父亲的身高与出生体重(r=0.19)和出生长度(r=0.33)相关，而与父亲的BMI无关。这与潜在的混杂因素和母亲的身高无关。所有胎儿骨骼生长的测量，包括头臀、膝跟和头围，都与父亲的身高有关。母亲身高与出生体重(r=0.18)和出生长度(r=0.26)的相关性相似。母亲BMI与出生体重(r=0.27)、出生长度(r=0.15)呈正相关。在多因素分析中，38%的胎儿身高变异可以由妊娠、性别、父亲身高、母亲身高、母亲血糖、母亲体重指数、产次和母亲吸烟来解释。结论：父亲身高对出生时身高有独立影响。这主要影响婴儿的长度和骨骼生长。与母亲肥胖不同，父亲肥胖的程度不会影响出生体重。这项工作表明，骨骼生长存在遗传调节，而母体环境主要改变胎儿的肥胖症。(C)2005爱思唯尔爱尔兰有限公司。保留所有权利。
Background: Genetic as well as environmental factors are important determinants of fetal growth but there have been few studies of the influence of paternal factors on fetal. growth.Aim: To study the influence of paternal anthropometry on detailed measurements of offspring at birth.Design: A prospective cohort study involving biochemistry, and anthropometry, of mothers and fathers at 28 weeks gestation, and detailed anthropometry of children within 24 h of birth.Subjects: 567 White Caucasian singleton, non-diabetic, full term pregnancies recruited from central Exeter, UK.Results: Paternal height, but not paternal BMI, was correlated with birth weight (r=0.19) and with birth Length (r=0.33). This was independent of potential confounders and maternal height. All measurements of fetal skeletal growth including crown-rump, knee-heel and head circumference were associated with paternal height. Maternal height showed similar correlations with birth weight (r=0.18) and birth length (r=0.26). Maternal BMI was correlated with birth weight (r=0.27) and birth length (r=0.15). In a multifactorial analysis 38% of the variance in fetal height could be explained by gestation, sex, paternal height, maternal height, maternal glucose, maternal BMI, parity and maternal smoking.Conclusion: Paternal height has an independent influence on size at birth. This predominantly influences length and skeletal growth of the baby. In contrast to maternal obesity the degree of paternal obesity does not influence birth weight. This work suggests that there is genetic regulation of skeletal growth while the maternal environment predominantly alters the adiposity of the fetus. (c) 2005 Elsevier Ireland Ltd. All rights reserved.