ANP is cleared much faster than BNP in patients with congestive heart failure
ANP is cleared much faster than BNP in patients with congestive heart failure
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DOI：
10.1007/s00228-007-0309-1
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发表时间：
2007-07-01
影响因子：
2.9
通讯作者：
Saito, Yoshihiko
中科院分区：
文献类型：
--
作者：
Kimura, Kuniko;Yamaguchi, Yukinari;Saito, Yoshihiko
目的了解心钠素（ANP）和脑钠素（BNP）在充血性心力衰竭（CHF）患者体内的药代动力学。虽然这两种肽发挥其作用，通过结合到一个共同的受体（利钠肽受体A）具有相同的亲和力，他们各自的负荷和维持dosedifferent.Methods CHF患者16人随机输注2小时与α-人心钠素（0.05 μ g/kg每分钟）或BNP（0.01 μ g/kg每分钟）。输注后0、2、5、15、30、60和120分钟测量两种肽的血浆浓度。结果ANP组和BNP组输注前血浆BNP浓度分别为464.7 ± 339.8pg/ml和506.8 ± 332.5pg/ml。输注后，ANP从循环中消失的速度比BNP更快：血浆半衰期分别为2.4 ± 0.7和12.1 ± 3.0 min，总清除率分别为48.2 ± 24.1和10.1 ± 2.7 ml/min/kg。结论CHF患者血浆中ANP的半衰期较BNP短，这表明它比BNP更容易控制血液动力学。
Objective To obtain a better understanding of the pharmacokinetics of atrial and brain natriuretic peptides (ANP and BNP, respectively), two peptide mediators used in the treatment of congestive heart failure (CHF). Although both peptides exert their effects by binding to a common receptor (natriuretic peptide receptor A) with about the same affinity, their respective loading and maintenance doses differ.Methods Sixteen CHF patients were randomized to be infused for 2 h with alpha-human ANP (0.05 mu g/kg per minute) or BNP (0.01 mu g/kg per minute). Plasma concentrations of both peptides were measured 0, 2, 5, 15, 30, 60 and 120 min post-infusion. The pharmacokinetic parameters were then calculated using a 1-compartment model.Results The plasma BNP concentrations in the ANP and BNP groups before infusion were 464.7 +/- 339.8 and 506.8 +/- 332.5 pg/ml, respectively. Following infusion, ANP disappeared from the circulation more rapidly than BNP: their plasma half-lives were 2.4 +/- 0.7 and 12.1 +/- 3.0 min, and their total body clearance volumes were 48.2 +/- 24.1 and 10.1 +/- 2.7 ml/min per kilogram, respectively.Conclusion ANP has a shorter half-life in the plasma of CHF patients than BNP, which suggests that it controls hemodynamics more readily than BNP.