Comparison of the effects of independently-controlled end-tidal PCO2 and PO2 on blood oxygen level-dependent (BOLD) MRI
Comparison of the effects of independently-controlled end-tidal PCO2 and PO2 on blood oxygen level-dependent (BOLD) MRI
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DOI：
10.1002/jmri.21102
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发表时间：
2008-01-01
影响因子：
4.4
通讯作者：
Mikulis, David
中科院分区：
文献类型：
--
作者：
Prisman, Eitan;Slessarev, Marat;Mikulis, David
目的：通过血氧水平依赖（BOLD）信号在CO2末分压（PETCO2）循环变化过程中的变化，评估O-2末分压（PETO2）变化对脑血管反应性（CVR）的影响。材料与方法：研究了四名健康志愿者对PETCO2（范围= 30.4-48.8 mmHg）和PETO2（范围= 100.6-444.0 mmHg）固定循环阶跃变化的BOLD反应。结果：全脑BOLD对PETO2和PETO2的反应性分别为0.283(0.188 ~ 0.379)（中位，范围）和0.004 (0.003 ~ 0.006)%/mmHg；灰质分别为0.438（0.382-0.614）和0.006 (0.004-0.009)%/mmHg；在白质中分别为0.075（0.065-0.093）和0.002 (0.001- 0.002)%/mmHg。结论：BOLD对PETO2的反应性远小于PETCO2。然而，co2诱导的PETO2变化会显著扭曲BOLD的反应性。我们的结论是，在使用BOLD反应性作为CVR指标的研究中，应仔细控制PETO2。
Purpose: To assess the effect of changes in end-tidal partial pressure of O-2 (PETO2) on cerebrovascular reactivity (CVR) estimated from changes in blood oxygen level-dependent (BOLD) signal during cyclic changes in end-tidal partial pressure of CO2 (PETCO2).Materials and Methods: BOLD response to fixed cyclic step changes in PETCO2 (range = 30.4-48.8 mmHg) and PETO2 (range = 100.6-444.0 mmHg) was studied in four healthy volunteers.Results: The BOLD reactivity to PETO2 and PETO2 were 0.283 (0.188-0.379) (median, range) and 0.004 (0.003-0.006)%/mmHg, respectively, in the whole brain; 0.438 (0.382-0.614) vs. 0.006 (0.004-0.009)%/mmHg, respectively, in the gray matter; and 0.075 (0.065-0.093) vs. 0.002 (0.001- 0.002)%/mmHg, respectively, in the white matter.Conclusion: The BOLD reactivity to PETO2, was much smaller than that to PETCO2. However, BOLD reactivity can be significantly distorted by CO2-induced changes in PETO2. We conclude that PETO2 should be carefully controlled during studies that use BOLD reactivity as an indicator of CVR.