Effect of sesamin on serum cholesterol and triglycerides levels in LDL receptor-deficient mice
Effect of sesamin on serum cholesterol and triglycerides levels in LDL receptor-deficient mice
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芝麻素对LDL受体缺陷小鼠血清胆固醇和甘油三酯水平的影响
DOI：
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发表时间：
2006
影响因子：
5
通讯作者：
H. Adlercreutz
中科院分区：
文献类型：
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作者：
J. Peñalvo;A. Hopia;H. Adlercreutz
背景芝麻素是芝麻籽中的一种主要木脂素，在以前的报道中与胆固醇降低有关，但最近的研究表明，根据所研究的模型以及所用芝麻素制剂的性质，对芝麻素摄入的反应存在差异。在胆固醇喂养条件下的基因敲除小鼠设计将动物随机分为4组，喂养含有甾烷醇酯，芝麻素，结果对照组显示出几乎3- 10个月的时间，由于致动脉粥样硬化饮食，血清胆固醇水平增加一倍，但对甘油三酯水平没有影响。Stanol酯单独或与芝麻素一起显着衰减的Elevation of the cholesterol levels.ConclusionSesamin单独没有影响的饮食诱导的胆固醇水平的升高，它没有增强的效果甾烷醇酯。
BackgroundSesamin, a major lignan from sesame seeds has been associated with cholesterol reduction in previous reports, but recent studies suggested differences in the response to sesamin intake depending on the model studied as well as the nature of the sesamin preparation used.AimThe effect of pure sesamin epimer on serum lipids was studied in hypercholesterolemic LDL receptor-knockout mice under cholesterol fed condition.DesignAnimals were randomly assigned to 4 groups, fed an atherogenic diet containing stanol ester, sesamin, combination of stanol ester and sesamin or a control diet with no additions.ResultsThe control group showed an almost 3-fold increase in serum cholesterol levels due to the atherogenic diet but no effect was seen for triglyceride levels. Stanol ester alone or together with sesamin significantly attenuated the elevation of the cholesterol levels.ConclusionSesamin alone did not affect the elevation of the diet-induced cholesterol level and it did not enhance the effect of stanol ester.
影响因子：
15.9
作者：
ISHIBASHI, S;BROWN, MS;HERZ, J
通讯作者：
HERZ, J
影响因子：
8.7
作者：
Lichtman, AH;Clinton, SK;Cybulsky, MI
通讯作者：
Cybulsky, MI