Mother-to-child transmission of GB virus C in a cohort of women coinfected with GB virus C and HIV in Bangkok, Thailand.
Mother-to-child transmission of GB virus C in a cohort of women coinfected with GB virus C and HIV in Bangkok, Thailand.
复制标题
泰国曼谷一组同时感染 GB 病毒 C 和 HIV 的妇女中 GB 病毒 C 的母婴传播。
DOI：
10.1086/599793
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发表时间：
2009
期刊：
影响因子：
--
通讯作者：
Butera,S
中科院分区：
文献类型：
--
作者：
BhanichSupapol,W;Remis,RS;Raboud,J;Millson,M;Tappero,J;Kaul,R;Kulkarni,P;McConnell,MS;Mock,PA;McNicholl,JM;Vanprapar,N;Asavapiriyanont,S;Shaffer,N;Butera,S
BackgroundGB virus C (GBV-C) is an apathogenic virus that inhibits human immunodeficiency virus (HIV) replication in vitro. Mother-to-child transmission (MTCT) of GBV-C has been observed in multiple small studies. Our study examined the rate and correlates of MTCT of GBV-C in a large cohort of GBV-C–HIV-coinfected pregnant women in ThailandMethodsMaternal delivery plasma specimens from 245 GBV-C–HIV-infected women and specimens from their infants at 4 or 6 months of age were tested for GBV-C RNA. Associations with MTCT of GBV-C were examined using logistic regressionResultsOne hundred one (41%) of 245 infants acquired GBV-C infection. MTCT of GBV-C was independently associated with maternal antiretroviral therapy (adjusted odds ratio [AOR], 5.21 [95% confidence interval {CI}, 2.12–12.81]), infant HIV infection (AOR, 0.05 [95% CI, 0.01–0.26]), maternal GBV-C load (⩾8.0 log10copies/mL: AOR, 86.77 [95% CI, 15.27–481.70]; 7.0–7.9 log10copies/mL: AOR, 45.62 [95% CI, 8.41–247.51]; 5.0–6.9 log10copies/mL: AOR, 9.07 [95% CI, 1.85–44.33]: reference, <5 log10viral copies/mL), and caesarean delivery (AOR, 0.26 [95% CI, 0.12–0.59])ConclusionsAssociations with maternal GBV-C load and mode of delivery suggest transmission during pregnancy and delivery. Despite mode of delivery being a common risk factor for virus transmission, GBV-C and HIV were rarely cotransmitted. The mechanisms by which maternal receipt of antiretroviral therapy might increase MTCT of GBV-C are unknown
