Association of serum estrogen level and ischemic neuroprotection in female rats
Association of serum estrogen level and ischemic neuroprotection in female rats
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DOI：
10.1016/s0304-3940(00)01704-3
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发表时间：
2001-01-19
影响因子：
2.5
通讯作者：
Chen, CJ
中科院分区：
文献类型：
--
作者：
Liao, SL;Chen, WY;Chen, CJ
雌激素相关的缺血性神经保护作用已在雄性和切除卵巢的雌性大鼠中得到证实。雌激素神经保护作用的精确分子机制仍不清楚。在本研究中，我们检查了内源性雌激素水平是否影响正常循环雌性大鼠的缺血后结果。颈总动脉和右侧大脑中动脉的闭塞（1.5小时）随后再灌注（24小时）导致皮质梗塞，中性粒细胞积累增加，抗氧化酶和乳酸脱氢酶活性升高。这些缺血后的变化在雌性大鼠中有所不同，并且与循环雌激素水平呈负相关。在正常循环的雌性大鼠中，更严重的缺血后变化和损伤伴随着循环雌激素水平的下降，这表明雌激素可能是雌性抵抗缺血的主要激素。 (C) 2001 Elsevier Science Ireland Ltd. 保留所有权利。
Estrogen-related ischemic neuroprotection has been documented in male and ovariectomized female rats. The precise molecular mechanism underlying estrogen's neuroprotective effect remains obscure. In the present study, we examined whether endogenous estrogen levels affect post-ischemic outcomes in normal cycling female rats. Occlusion of both the common carotid arteries and the right middle cerebral artery (1.5 h) followed by reperfusion (24 h) caused cortical infarction, increased neutrophil accumulation, and elevated antioxidant enzyme and lactate dehydrogenase activities. These post-ischemic changes varied in the female rats and were inversely correlated with circulating estrogen levels. More severe post-ischemic changes and injury accompanied the decline in circulating estrogen levels in normal cycling female rats, indicating that estrogen is probably the major hormonal player in female resistance to ischemia. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.