The role of brain norepinephrine in clonidine suppression of isolation-induced distress in the domestic chick
The role of brain norepinephrine in clonidine suppression of isolation-induced distress in the domestic chick
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脑去甲肾上腺素在可乐定抑制家鸡隔离应激中的作用
DOI：
10.1007/bf00433414
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发表时间：
2004
影响因子：
3.4
通讯作者：
J. Panksepp
中科院分区：
文献类型：
--
作者：
J. Rossi;T. L. Sahley;J. Panksepp
在1日龄家鸡侧脑室注射药物后，通过去甲肾上腺素能系统测定了由社会隔离引起的痛苦发声（DV）。α-肾上腺素受体激动剂可乐定在低至0.08 μg的剂量下可靠地抑制DV率。当单独给药时，酚妥拉明、酚苄明、普萘洛尔、索他洛尔和育亨宾（肾上腺素受体拮抗剂）在无毒剂量下的DV率后不可靠。育亨宾（1.75 μg）能可靠地逆转可乐定DV的抑制作用，而其他肾上腺素受体拮抗剂或纳洛酮均不能逆转。6-羟基多巴胺在高达120 μg的剂量下，基本上消除了前脑去甲肾上腺素，当单独给药时，不能可靠地抑制DV率，当与可乐定（0.1 μg）或吗啡（0.05 μg）联合给药时，不能逆转这些药物对DV的严重抑制。结果表明，可乐定通过与突触后肾上腺素受体相互作用或通过除连接前α2-肾上腺素受体刺激以外的其他方式抑制雏鸡DV率。
Distress vocalizations (DV) induced by social isolation were measured in 1-day-old domestic chicks after intracerebroventricular injections of drugs believed to exert their effects through the noradrenergic system. The α-adreno-receptor agonist clonidine reliably suppressed DV rates at doses low as 0.08 μg. When given alone, phentolamine, phenoxybenzamine, propranolol, sotalol, and yohimbine (adrenoreceptor antagonists) did not reliably after DV rates at doses that were not toxic. The clonidine DV suppression was reliably reversed by yohimbine (1.75 μg), but by none of the other adrenoceptor antagonists or naloxone. 6-Hydroxydopamine at doses as high as 120 μg, which essentially eliminated forebrain norepinephrine, failed to suppress DV rates reliably when given alone and, when given in combination with clonidine (0.1 μg) or morphine (0.05 μg), failed to reverse the severe DV suppression imposed by these drugs. The results suggest that clonidine suppresses DV rates in chicks through interaction with postsynaptic adrenoreceptors or by some means other than prejunctional α2-adrenoreceptor stimulation.