A FAMILY STUDY OF A MOTHER AND DAUGHTER WITH INCREASED SUSCEPTIBILITY TO EARLY-ONSET PERIODONTITIS - MICROBIOLOGICAL, IMMUNOLOGICAL, HOST DEFENSIVE, AND GENETIC ANALYSES
A FAMILY STUDY OF A MOTHER AND DAUGHTER WITH INCREASED SUSCEPTIBILITY TO EARLY-ONSET PERIODONTITIS - MICROBIOLOGICAL, IMMUNOLOGICAL, HOST DEFENSIVE, AND GENETIC ANALYSES
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DOI：
10.1902/jop.1990.61.12.755
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发表时间：
1990-12-01
影响因子：
4.3
通讯作者：
KATO, K
中科院分区：
文献类型：
--
作者：
NISHIMURA, F;NAGAI, A;KATO, K
对一对患有早发性牙周炎（母亲为快速进展性牙周炎；女儿为局限性幼年性牙周炎）的母亲和女儿进行了微生物学、免疫学、宿主防御和遗传分析。显微镜检查显示，两名受试者体内的杆状细菌百分比都大大增加。梭杆菌属牙龈卟啉单胞菌（以前称为牙龈拟杆菌）是培养的主要微生物。两名受试者对具核梭菌、牙龈卟啉单胞菌和伴放线放线杆菌的体液免疫反应比对任何其他检查的牙周细菌的体液免疫反应要高得多。外周淋巴细胞的功能和表型分析未显示明显异常。然而，中性粒细胞功能的调查表明，母亲的中性粒细胞趋化性和超氧化物产生受到抑制。女儿不仅趋化性和超氧化物产生受到抑制，而且中性粒细胞的吞噬作用也受到抑制。 HLA 抗原的血清学分型显示，两名受试者具有相同的 II 类 HLA 谱。结论是，两名受试者很可能患有相同的病症，并且这些患者为提高我们对牙周病宿主因素的理解提供了独特的模型。
Microbiological, immunological, host-defensive, and genetic analyses were performed on a mother and daughter, both of whom had early-onset periodontitis (rapidly progressive periodontitis in the mother; localized juvenile periodontitis in the daughter). Microscopic examination revealed a greatly elevated percentage of rod-form bacteria in both subjects. Fusobacterium sp. and Porphyromonas gingivalis (formerly Bacteroides gingivalis) were the predominant microorganisms cultured. The humoral immune responses to F. nucleatum, P. gingivalis, and Actinobacillus actinomycetemcomitans were much higher in both subjects than those to any other periodontal bacteria examined. Functional and phenotypic analysis of the peripheral lymphocytes showed no significant abnormalities. However, investigation of neutrophil function showed that the mother had depressed neutrophil chemotaxis and superoxide production. The daughter had depression not only of chemotaxis and superoxide production, but also of neutrophil phagocytosis. Serological typing of HLA antigens revealed the same Class II HLA profile in both subjects. It was concluded that both subjects very probably had an identical condition and that these patients provided a unique model for improving our understanding of the host factors involved in periodontal disease.