Baseline characteristics in relation to electrocardiographic left ventricular hypertrophy in hypertensive patients -: The Losartan Intervention for Endpoint reduction (LIFE) in hypertension study
Baseline characteristics in relation to electrocardiographic left ventricular hypertrophy in hypertensive patients -: The Losartan Intervention for Endpoint reduction (LIFE) in hypertension study
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DOI：
10.1161/01.hyp.36.5.766
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发表时间：
2000-11-01
期刊：
影响因子：
8.3
通讯作者：
Dahlöf, B
中科院分区：
文献类型：
--
作者：
Okin, PM;Devereux, RB;Dahlöf, B
氯沙坦干预降低高血压终点（LIFE）研究是一项双盲、前瞻性、平行组研究，旨在比较氯沙坦与阿替洛尔在降低心血管发病率和死亡率方面的作用。共9194例高血压伴ECG左心室肥厚（LVH）患者（根据Cornell电压-持续时间乘积和/或Sokolow-Lyon电压标准）入组本研究，8785例患者（54%为女性;平均年龄67 ± 7岁）的基线临床和ECG数据可用。根据Cornell电压-持续时间乘积标准，5791例患者存在ECG LVH（65.9%）和2025例患者的Sokolow-Lyon电压与Cornell电压-时程乘积标准无左室肥厚的患者相比，本方法检出的左室肥厚患者年龄大、肥胖、女性、白色、从不吸烟者多;更可能患有糖尿病和心绞痛;收缩压、舒张压和脉搏压略高。相比之下，根据Sokolow-Lyon标准，ECG LVH的患者略年轻;不太肥胖;更可能是男性、黑人和目前吸烟者;不太可能患有糖尿病;更可能患有心绞痛和脑血管疾病史;收缩压和脉搏压较高，但舒张压略低于根据该方法没有ECG LVH的患者。通过使用多变量logistic回归分析，根据Cornell电压-持续时间乘积标准，ECG LVH的存在主要与较高的体重指数、年龄增加和女性相关，而根据Sokolow-Lyon电压标准，ECG LVH的存在主要与较低的体重指数、男性和黑人赛车相关：因此，高血压患者谁满足康奈尔产品和Sokolow-Lyon电压标准与不同的，但潜在的同样不利的，危险因素的档案。
The Losartan Intervention For Endpoint (LIFE) reduction in hypertension study is a double-blind, prospective, parallel group study designed to compare the effects of losartan with those of atenolol on the reduction of cardiovascular morbidity and mortality. A total of 9194 patients with hypertension and ECG left ventricular hypertrophy (LVH) by Cornell voltage-duration product and/or Sokolow-Lyon voltage criteria were enrolled in the study, with baseline clinical and ECG data available in 8785 patients (54% women; mean age, 67 +/- 7 years). ECG LVH by Cornell voltage-duration product criteria was present in 5791 patients (65.9%) and by Sokolow-Lyon voltage in 2025 patients (23.1%), Compared with patients without ECG LVH by Cornell voltage-duration product criteria, patients with ECG LVH by this method were:older; more obese; more likely to be female, white, and to have never smoked; more likely to be diabetic and have angina; and had slightly higher systolic, diastolic, and pulse blood pressures. In contrast, patients with ECG LVH by Sokolow-Lyon criteria were slightly younger; less obese; more likely to be male, black, and current smokers; less likely to have diabetes; more likely to have angina and a history of cerebrovascular disease; and had higher systolic and pulse blood pressure but slightly lower diastolic blood pressure than patients without ECG LVH by this method. By use of multivariate logistic regression analyses, presence of ECG LVH by Cornell voltage-duration product criteria was predominantly associated with higher body mass index, increased age, and female gender, whereas presence of ECG LVH by Sokolow-Lyon voltage criteria was predominantly related to lower body mass index, male gender, and black racer: Thus, hypertensive patients who meet Cornell product and Sokolow-Lyon voltage criteria are associated with different, but potentially equally adverse, risk factor profiles.