Race & sex disparities related to low-dose computed tomography lung cancer screening eligibility criteria: A lung cancer cases review.
Race & sex disparities related to low-dose computed tomography lung cancer screening eligibility criteria: A lung cancer cases review.
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与低剂量计算机断层扫描肺癌筛查资格标准相关的种族和性别差异：肺癌病例回顾
DOI：
10.1016/j.lungcan.2022.05.008
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发表时间：
2022-07
期刊：
影响因子：
5.3
通讯作者：
Tammemagi, Martin C.
中科院分区：
文献类型：
--
作者：
Williams, Randi M.;Kareff, Samuel A.;Sackstein, Paul;Roy, Tina;Luta, George;Kim, Chul;Taylor, Kathryn L.;Tammemagi, Martin C.
关键词：
美国预防服务工作组(USPSTF)的建议没有考虑到肺癌风险的种族和性别差异。我们比较了USPSTF 2013建议与PLCOm2012模型在相同阈值下发现符合肺癌筛查(LCS)条件的肺癌病例的敏感度。使用乔治敦大学医院肿瘤登记系统，我们确定了2014年至2018年间的肺癌病例(≥，55岁)。回顾收集的年龄、性别、种族、教育程度、吸烟和临床特征的病历。我们比较了总体上符合资格标准的百分比，并按种族和性别进行了比较。447例中黑人占36.6%，女性占52.6%。PLCOm2012和USPSTF2013标准分别确定了71.4%和45.6%的病例(p<；0.0001)。这一差异在种族和性别亚组中是一致的(p<；0.0001)。在黑人(69.9%比46.6%，p<；0.0001)和女性(69.8%比41.3%，p<；0.0001)中，PLCOm2012比USPSTF更敏感。USPSTF对两个种族的敏感性都很低(黑人46.6%，白人45.9%，p=0.886)，女性的敏感性低于男性(41.3%比51.4%，p=0.032)。PLCOM2012在女性和男性中的敏感性较高，性别差异不显著(69.8%vs.72.6%，p=0.506)。与USPSTF 2013年的建议相比，PLCOm2012模型在所有种族-性别阶层中选择了更大比例的肺癌病例，并消除了USPSTF观察到的性别差异。PLCOm2012风险模型可以用来确定哪些人将从LCS中受益。
The United States Preventive Services Task Force (USPSTF) recommendations do not account for race and sex differences in lung cancer risk. We compared the sensitivity for finding lung cancer cases eligible for lung cancer screening (LCS) by USPSTF 2013 recommendations versus the PLCOm2012 model at an equivalent threshold. Using Georgetown University Hospital tumor registry, we identified lung cancer cases (≥55 years old) between 2014–2018. Medical chart review collected age, sex, race, education, smoking, and clinical characteristics. We compared the percentage meeting eligibility criteria overall, and by race and sex. The cases (N=447) were 36.6% Black and 52.6% female. The PLCOm2012 and USPSTF 2013 criteria identified 71.4% and 45.6% of cases, respectively (p<0.0001). This difference was consistent across race and sex sub-groups (p<0.0001). The PLCOm2012 was more sensitive than the USPSTF in Blacks (69.9% vs. 46.6%, p<0.0001) and in women (69.8% vs. 41.3%, p<0.0001). The USPSTF had poor sensitivity for both race groups (Black 46.6%, White 45.9%, p=0.886) and had lower sensitivity in women vs. men (41.3% vs. 51.4%, p=0.032). The PLCOm2012 had higher sensitivities in women and men, and difference between sexes was not significant (69.8% vs. 72.6%, p=0.506). Compared to the USPSTF 2013 recommendations, the PLCOm2012 model selected a larger proportion of lung cancer cases in all race-sex strata and removed the sex disparity observed for the USPSTF. The PLCOm2012 risk model could be used to identify those who will benefit from LCS.
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影响因子：
15.8
作者：
Ten Haaf K;Tammemägi MC;Bondy SJ;van der Aalst CM;Gu S;McGregor SE;Nicholas G;de Koning HJ;Paszat LF
通讯作者：
Paszat LF
DOI：
10.1164/rccm.201502-0259oc
发表时间：
2015-07-15
影响因子：
24.7
作者：
Tanner, Nichole T.;Gebregziabher, Mulugeta;Silvestri, Gerard A.
通讯作者：
Silvestri, Gerard A.
影响因子：
13.8
作者：
Reese TJ;Schlechter CR;Potter LN;Kawamoto K;Del Fiol G;Lam CY;Wetter DW
通讯作者：
Wetter DW
影响因子：
9.6
作者：
Pasquinelli, Mary M.;Tammemagi, Martin C.;Feldman, Lawrence E.
通讯作者：
Feldman, Lawrence E.
影响因子：
120.7
作者：
Meza, Rafael;Jeon, Jihyoun;Toumazis, Iakovos;ten Haaf, Kevin;Cao, Pianpian;Bastani, Mehrad;Han, Summer S.;Blom, Erik F.;Jonas, Daniel E.;Feuer, Eric J.;Plevritis, Sylvia K.;de Koning, Harry J.;Kong, Chung Yin
通讯作者：
Kong, Chung Yin