Strain estimation in phase-sensitive optical coherence elastography.
Strain estimation in phase-sensitive optical coherence elastography.
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DOI：
10.1364/boe.3.001865
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发表时间：
2012-08-01
影响因子：
3.4
通讯作者：
Sampson DD
中科院分区：
文献类型：
--
作者：
Kennedy BF;Koh SH;McLaughlin RA;Kennedy KM;Munro PR;Sampson DD
我们提出了一个理论框架，在光学相干弹性成像（OCE）的应变估计，从机械加载样品获得的位移测量的统计分析的基础上。我们定义应变灵敏度，信噪比和动态范围，并获得估计的应变使用三种方法：有限差分，普通最小二乘法和加权最小二乘法，后者首次在OCE。我们比较理论预测与实验结果，并证明了~12 dB的改进，应变灵敏度加权最小二乘相比，有限差分应变估计和~4 dB的改进，普通最小二乘应变估计。我们呈现应变图像（即，弹性图），在每种情况下基于样品的弹性显示出清晰的对比。
We present a theoretical framework for strain estimation in optical coherence elastography (OCE), based on a statistical analysis of displacement measurements obtained from a mechanically loaded sample. We define strain sensitivity, signal-to-noise ratio and dynamic range, and derive estimates of strain using three methods: finite difference, ordinary least squares and weighted least squares, the latter implemented for the first time in OCE. We compare theoretical predictions with experimental results and demonstrate a ~12 dB improvement in strain sensitivity using weighted least squares compared to finite difference strain estimation and a ~4 dB improvement over ordinary least squares strain estimation. We present strain images (i.e., elastograms) of tissue-mimicking phantoms and excised porcine airway, demonstrating in each case clear contrast based on the sample’s elasticity.