Regulation of Cellular Response Pattern to Phosphorus Ion is a New Target for the Design of Tissue‐Engineered Blood Vessel
Regulation of Cellular Response Pattern to Phosphorus Ion is a New Target for the Design of Tissue‐Engineered Blood Vessel
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DOI：
10.1002/adhm.201400763
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发表时间：
2015-05
影响因子：
10
通讯作者：
Wen Chen;Fangjuan Wang;W. Zeng;Jun Sun;Li Li-Li;Mingcan Yang;Jian-sen Sun;Yangxiao Wu;Xiaohui Zhao;Chuhong Zhu
中科院分区：
文献类型：
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作者：
Wen Chen;Fangjuan Wang;W. Zeng;Jun Sun;Li Li-Li;Mingcan Yang;Jian-sen Sun;Yangxiao Wu;Xiaohui Zhao;Chuhong Zhu
调控细胞对磷离子（PI）的反应模式是组织工程材料设计的新目标。改变细胞对高PI的反应模式可以维持TEBV中单核/巨噬细胞的存活，PI升高的信号可以通过klotho调节单核/巨噬细胞的能量代谢将其转化为腺苷信号。
Regulation of cellular response pattern to phosphorus ion (PI) is a new target for the design of tissue-engineered materials. Changing cellular response pattern to high PI can maintain monocyte/macrophage survival in TEBV and the signal of increasing PI can be converted by klotho to the adenosine signals through the regulation of energy metabolism in monocytes/macrophages.