MYCOTOXINS PRODUCED BY ASPERGILLUS-FUMIGATUS SPECIES ISOLATED FROM MOLDED SILAGE
MYCOTOXINS PRODUCED BY ASPERGILLUS-FUMIGATUS SPECIES ISOLATED FROM MOLDED SILAGE
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DOI：
10.1021/jf60212a015
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发表时间：
1977-01-01
影响因子：
6.1
通讯作者：
COX, RH
中科院分区：
文献类型：
--
作者：
COLE, RJ;KIRKSEY, JW;COX, RH
结果强烈表明烟曲霉菌株是模制玉米青贮饲料中的主要真菌之一。从模制青贮饲料中分离出的烟曲霉菌株产生了棒麦角生物碱、烟曲棒碱A、命名为烟棒棒碱C的新生物碱和属于烟曲霉组的几种震颤素。日龄公鸡口服烟加棒碱 C 的 LD50 约为 150 mg/kg。服用烟曲霉培养物粗提物的小牛出现严重腹泻、烦躁和食欲不振。尸检显示有浆液性肠炎和肺部间质变化的证据；其他组织未见异常变化。
Results are presented which strongly suggest that strains of A. fumigatus are one of the predominant fungi in molded corn silage. The clavine alkaloids, fumigaclavine A, a new alkaloid designated fumigaclavine C and several tremorgens belonging to the fumitremorgen group were produced by A. fumigatus strains isolated from molded silage. The LD50 of fumigaclavine C was about 150 mg/kg oral dose in day-old cockerels. Calves dosed with crude extracts of A. fumigatus cultures experienced severe diarrhea, irritability and loss of appetite. Postmortem examination showed serous enteritis and evidence of interstitial changes in the lungs; abnormal changes were not found in other tissues.