Olfactory impairment is related to REM sleep deprivation in rotenone model of Parkinson's disease.
Olfactory impairment is related to REM sleep deprivation in rotenone model of Parkinson's disease.
复制标题
帕金森病鱼藤酮模型中嗅觉障碍与快速眼动睡眠剥夺有关。
DOI：
10.5935/1984-0063.20170008
复制
发表时间：
2017-01
期刊：
影响因子：
--
通讯作者：
Lima MMS
中科院分区：
文献类型：
--
作者：
Aurich MF;Rodrigues LS;Targa ADS;Noseda ACD;Cunha FDW;Lima MMS
嗅觉功能障碍影响约85-90%的帕金森病（PD）患者，其辨别几种类型气味的能力严重恶化。此外，研究报告称，在短时间的睡眠剥夺期间，嗅觉表现会下降。此外，PD还强烈影响快速眼动（REM）睡眠的发生和维持。因此，我们调查的机制参与歧视的社会气味（依赖犁鼻系统）和非社会气味（相关的主要嗅觉通路）的鱼藤酮模型的PD。此外，伴随的损害REM睡眠造成了两个时期（24或48小时）的REM睡眠剥夺（REMSD）的介绍。鱼藤酮促进了显着的嗅觉障碍，在社会和非社会气味，与一个显着的调制诱导24小时的REMSD的非社会气味。我们的研究结果表明，黑质TH-免疫反应神经元的密度和嗅觉辨别能力的气味刺激之间的强关联的发生。具体而言，鱼藤酮诱导的这些神经元的减少往往会引起嗅觉辨别能力的降低。这些结果是一致的黑质纹状体多巴胺能系统的参与，主要是在嗅觉歧视的非社会气味，可能是通过主要的嗅觉通路。这种参与可能对PD患者中发现的临床前异常产生相关影响。
Olfactory dysfunction affects about 85-90% of Parkinson's disease (PD) patients with severe deterioration in the ability of discriminate several types of odors. In addition, studies reported declines in olfactory performances during a short period of sleep deprivation. Besides, PD is also known to strongly affect the occurrence and maintenance of rapid eye movement (REM) sleep. Therefore, we investigated the mechanisms involved on discrimination of a social odor (dependent on the vomeronasal system) and a non-social odor (related to the main olfactory pathway) in the rotenone model of PD. Also, a concomitant impairment in REM sleep was inflicted with the introduction of two periods (24 or 48 h) of REM sleep deprivation (REMSD). Rotenone promoted a remarkable olfactory impairment in both social and non-social odors, with a notable modulation induced by 24 h of REMSD for the non-social odor. Our findings demonstrated the occurrence of a strong association between the density of nigral TH-ir neurons and the olfactory discrimination capacity for both odorant stimuli. Specifically, the rotenone-induced decrease of these neurons tends to elicit reductions in the olfactory discrimination ability. These results are consistent with the participation of the nigrostriatal dopaminergic system mainly in the olfactory discrimination of a non-social odor, probably through the main olfactory pathway. Such involvement may have produce relevant impact in the preclinical abnormalities found in PD patients.