LONG-TERM RESULTS OF CONCURRENT CHEMORADIOTHERAPY USING LOW-DOSE CONTINUOUS INFUSION OF 5-FLUOROURACIL FOR STAGE II-III ESOPHAGEAL CANCER
LONG-TERM RESULTS OF CONCURRENT CHEMORADIOTHERAPY USING LOW-DOSE CONTINUOUS INFUSION OF 5-FLUOROURACIL FOR STAGE II-III ESOPHAGEAL CANCER
复制标题
小剂量持续输注 5-氟尿嘧啶同步放化疗治疗 II-III 期食管癌的长期结果
DOI：
10.11182/jastro1989.13.97
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发表时间：
2001
期刊：
影响因子：
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通讯作者：
H. Inakoshi
中科院分区：
文献类型：
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作者：
K. Sakai;H. Sueyama;M. Saito;T. Sugita;E. Tsuchida;Y. Matsumoto;R. Sasamoto;T. Uematsu;J. Oda;Takeshi Ito;H. Inakoshi
目的：为了提高II-III期食道癌的局部控制率，我们尝试在常规放射治疗的整个过程中，采用小剂量持续滴注5-氟尿嘧啶(5-FU)的同步放化疗。材料和方法：43例符合条件的II-III期食道癌患者接受常规放疗60~70Gy5-FU(300 mg/m2/24小时)持续滴注，每周5天，疗程5~7周。所有患者在开始治疗后均获得5年以上的随访。结果：虽然有2例与治疗相关的死亡，但88%(38/43)的患者能够完成计划的放化疗疗程。有效率为90%。中位生存期为12.2个月，2年和5年总生存率分别为33%和15%。结论：小剂量5-FU全程持续滴注治疗II-III期食道癌是可行的，其疗效优于单纯放疗。
Purpose: To improve the local control of stage II-III esophageal cancer, we tried concurrent chemoradiotherapy with low-dose continuous infusion of 5-fluorouracil (5-FU) during the entire course of conventional radiotherapy. Material and Methods: Forty-three eligible patients with stage II-III esophageal cancer were treated with conventional radiotherapy up to 60-70 Gy concurrently with continuous infusion of 5-FU (300mg/m2 per 24 hours) for 5 days per week given over 5 to 7 weeks. All patients were followed up more than 5 years after starting the treatments. Results: Although there were two treatment-related deaths, 88% of the patients (38/43) could complete the planned course of chemoradiotherapy. Response rate was 90%. The median survival time was 12.2 months, and the 2and 5-year overall survival rates were 33% and 15%, respectively. Conclusion: Low-dose continuous infusion of 5-FU given during the entire course of conventional radiotherapy is feasible and seems to offer better results than radiotherapy alone in the treatment of stage II-III esophageal cancer.