Risk factors for breast cancer by oestrogen receptor status: a population-based case-control study.
Risk factors for breast cancer by oestrogen receptor status: a population-based case-control study.
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DOI：
10.1038/bjc.1989.24
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发表时间：
1989-01
影响因子：
8.8
通讯作者：
Tilley, W D
中科院分区：
文献类型：
--
作者：
Cooper, J A;Rohan, T E;Cant, E L;Horsfall, D J;Tilley, W D
在南澳的阿德莱德进行的一项基于人群的病例对照研究中，对451个病例对照对的数据进行了分析，以确定月经、生殖、饮食和其他因素与乳腺癌风险的关系是否因雌激素受体（ER）状态而异。380例病例的ER状态数据可用。ER+肿瘤的比例随着年龄的增长而增加，绝经后女性ER+肿瘤的比例高于绝经前女性。口服避孕药（P = 0.055）和吸烟（P = 0.047）均与ER-癌症风险增加（未校正）相关，而与ER+癌症风险几乎无关。大多数饮食因素与两种癌症的风险几乎没有关联，主要的例外是随着β-胡萝卜素摄入量的增加，ER-乳腺癌的风险降低（趋势P = 0.017）。然而，总的来说，与检查的因素的联系并不足以表明ER-和ER+乳腺癌的不同因果途径。
Data from a population-based case-control study conducted in Adelaide, South Australia, and involving 451 case-control pairs, were analysed to determine whether the associations of menstrual, reproductive, dietary and other factors with risk of breast cancer differed by oestrogen receptor (ER) status. Data on ER status were available for 380 cases. The proportion of tumours which were ER+ increased with age, and there was a higher proportion of ER+ tumours in post-menopausal than in premenopausal women. Both oral contraceptive use (P = 0.055) and cigarette smoking (P = 0.047) were associated with increased (unadjusted) risk of ER- cancer, while having little association with risk of ER+ cancer. Most dietary factors had little association with risk of either cancer type, the main exception being the reduction in risk of ER- breast cancer with increasing beta-carotene intake (P for trend = 0.017). In general, however, links with the factors examined were not strong enough to suggest different causal pathways for ER- and ER+ breast cancer.