Human coronavirus-NL63 infection is not associated with acute Kawasaki disease.
Human coronavirus-NL63 infection is not associated with acute Kawasaki disease.
复制标题
人类冠状病毒-NL63感染与急性川崎病无关。
DOI：
10.1007/978-0-387-33012-9_94
复制
发表时间：
2006
影响因子：
--
通讯作者：
Burns,JC
中科院分区：
文献类型：
--
作者：
Baker,SC;Shimizu,C;Shike,H;Garcia,F;vanderHoek,L;Kuijper,TW;Reed,SL;Rowley,AH;Shulman,ST;Talbot,HKB;Williams,JV;Burns,JC
川崎病是一种常见于幼儿期的急性全身性血管炎。KD特别影响中等大小的动脉，如冠状动脉，并可导致冠状动脉瘤破裂，导致猝死。KD的临床和流行病学特征，包括急性发热、皮疹、结膜注射和宫颈腺炎，以及具有波状疾病传播的局灶性流行，与感染性病因一致（参考文献1）。事实上，目前的研究提供证据表明，KD中的IgA反应是针对支气管上皮和其他炎症组织中的抗原。然而，传统的方法未能确定KD的病因。最近，埃斯珀和他的同事报告了KD和一种他们称之为hcov -纽黑文（NH）的RNA病毒之间的联系。目前可获得的有限序列表明，HCoV-NH与2004年首次描述的HCoV-NL63高度相似。为了确定HCoV-NL63是否与KD相关，我们建立了一项多机构合作研究，使用RTPCR方法检测KD患者的呼吸道样本。我们发现48例KD患者中只有1例（2%）HcoV-NL63阳性。因此，这些结果表明呼吸道感染HcoV-NL63与急性KD无关。参考文献6提供了所有方法和结果的详细描述。
Kawasaki disease (KD) is an acute, systemic vasculitis generally seen in early childhood. KD particularly affects medium size arteries, such as coronary arteries, and can result in coronary artery aneurysms that rupture, causing sudden death. The clinical and epidemiologic features of KD, with acute onset of fever, rash, conjunctival injection and cervical adenitis, and focal epidemics with wave-like spread of illness, are consistent with an infectious etiology (reviewed in Ref. 1). Indeed, current studies provide evidence that the IgA response in KD is targeting antigen in the bronchial epithelium and other inflamed tissues. 2, 3 However, conventional methods have failed to identify the etiology of KD. Recently, Esper and colleagues reported an association between KD and a RNA virus they termed HCoV-New Haven (NH). 4 The limited sequence currently available indicates that HCoV-NH is highly similar to HCoV-NL63, which was initially described in 2004. 5 To determine if HCoV-NL63 was associated with KD, we established a multiinstitutional collaborative study to test respiratory samples from KD patients using RTPCR methods. We found that only 1 of 48 KD patients (2%) was positive for HcoV-NL63. Thus, these results indicate that respiratory tract infection with HcoV-NL63 is not associated with acute KD. A detailed description of all methods and results is provided in Ref. 6.