Decreased zinc in the development and progression of malignancy: an important common relationship and potential for prevention and treatment of carcinomas.
Decreased zinc in the development and progression of malignancy: an important common relationship and potential for prevention and treatment of carcinomas.
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DOI：
10.1080/14728222.2017.1265506
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发表时间：
2017-01
影响因子：
5.8
通讯作者：
Franklin RB
中科院分区：
文献类型：
--
作者：
Costello LC;Franklin RB
目前还没有有效的化疗来治疗或预防前列腺癌、肝癌和胰腺癌，以及其他一些恶性肿瘤中锌含量降低的癌症。锌处理提供了一个潜在的解决方案；但它的支持受到了负面偏见的阻碍。1. 共同的ZIP转运蛋白/Zn下调在这些癌症中的临床和实验证据。2. 锌疗法预防和/或治疗这些癌的证据。3. 引入对锌方法支持的偏见的问题。ZIP/Zn下调是前列腺癌、肝细胞癌和胰腺癌临床确定的常见事件。2. 令人信服的证据支持锌治疗方案可以预防恶性肿瘤的发展和终止这些癌症的进展性恶性肿瘤；其他癌症也可能表现出锌的减少。3. 科学上毫无根据的反对ZIP/Zn关系的问题导致了对支持锌治疗方法的研究和资助的偏见。4. 临床建立的和支持性的实验证据提供了科学可信度，应该支持锌疗法的研究和资助，以治疗和可能预防这些癌症。5. 这符合医学界和广大公众的最大利益。
Efficacious chemotherapy does not exist for treatment or prevention of prostate, liver, and pancreatic carcinomas, and some other cancers that exhibit decreased zinc in malignancy. Zinc treatment offers a potential solution; but its support has been deterred by adverse bias. 1. The clinical and experimental evidence for the common ZIP transporter/Zn down regulation in these cancers. 2. The evidence for a zinc approach to prevent and/or treat these carcinomas. 3. The issues that introduce bias against support for the zinc approach. ZIP/Zn downregulation is a clinically established common event in prostate, hepatocellular and pancreatic cancers. 2. Compelling evidence supports the plausibility that a zinc treatment regimen will prevent development of malignancy and termination of progressing malignancy in these cancers; and likely other carcinomas that exhibit decreased zinc. 3. Scientifically-unfounded issues that oppose this ZIP/Zn relationship have introduced bias against support for research and funding of a zinc treatment approach. 4. The clinically-established and supporting experimental evidence provide the scientific credibility that should dictate the support for research and funding of a zinc approach for the treatment and possible prevention of these cancers. 5. This is in the best interest of the medical community and the public-at-large.
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影响因子：
37.3
作者：
Costello, Leslie C;Franklin, Renty B
通讯作者：
Franklin, Renty B
DOI：
10.2174/1874303x00801010026
发表时间：
2008-01-01
期刊：
The open urology & nephrology journal
影响因子：
--
作者：
Costello, Leslie C;Franklin, Renty B;Tan, Ming T
通讯作者：
Tan, Ming T
影响因子：
1.6
作者：
Franklin, Renty B;Levy, Bernard A;Zou, Jing;Hanna, Nader;Desouki, Mohamed Mokhtar;Bagasra, Omar;Johnson, Leslie A;Costello, Leslie C
通讯作者：
Costello, Leslie C
影响因子：
9.7
作者：
Chen, Zhuo;Xu, Peng;Huang, Mingdong
通讯作者：
Huang, Mingdong
影响因子：
11.2
作者：
Ding, WQ;Liu, BL;Lind, SE
通讯作者：
Lind, SE