Predictors of antidepressant adherence: Results of a Japanese Internet-based survey
Predictors of antidepressant adherence: Results of a Japanese Internet-based survey
复制标题
DOI：
10.1111/j.1440-1819.2009.02058.x
复制
发表时间：
2010-01-01
影响因子：
11.9
通讯作者：
Nomura, Soichiro
中科院分区：
文献类型：
--
作者：
Shigemura, Jun;Ogawa, Tetsuo;Nomura, Soichiro
Aim: The purpose of the present study was to identify the psychosocial/pharmacological predictors of antidepressant ( AD) adherence.Methods: An Internet-based survey was conducted among 1151 Japanese individuals with major depressive disorder. Subjects were asked to report their degree of non-adherence for each AD taken using a 5-point Likert scale: 0, never forget; 1, rarely forget; 2, occasionally forget; 3, sometimes forget; and 4, often forget. The highest number reported among each subject was assigned as their low adherence index (LAI). Individuals with an LAI >= 3 were defined as members of the low adherence ( LA) group. Predictors of LA was analyzed using bivariate and multivariate models, both among the total number of subjects and single AD subgroup (n = 657).Results: Nearly one-third of subjects ( n = 381, 33.1%) reported LA. On bivariate analysis, LA was associated with lower age, worker or student status (vs unemployed or housewife), higher daily dosing frequency (DDF), low drug satisfaction, and a neutral/negative doctor-patient relationship (DPR; P < 0.001). In a multivariate model, LA was predicted by age (= twice daily: OR, 1.61), and neutral/negative DPR (OR, 1.54; P < 0.01). Among the single-AD subgroup, adherence was similar between those on selective serotonin reuptake inhibitors/serotonin-noradrenaline reuptake inhibitors and tricyclics. Use of neither medication was associated with adherence in a multivariate model.Conclusion: LA was predicted by lower age, worker or student status, higher DDF, and neutral/negative DPR. Adherence was not significantly different between subjects on newer agents and tricyclics.
