The Early Life of a Schwann Cell
The Early Life of a Schwann Cell
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DOI：
10.1515/bc.2002.026
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发表时间：
2002-01
期刊：
影响因子：
--
通讯作者：
C. Lobsiger;V. Taylor;U. Suter
中科院分区：
文献类型：
--
作者：
C. Lobsiger;V. Taylor;U. Suter
摘要雪旺细胞是脊椎动物周围神经系统的主要胶质细胞群。在成人中，它们在神经元突起和髓鞘化的大轴突周围建立保护鞘。在发育早期，许旺细胞和神经元就建立了密切的联系。周围神经的后期发育和维持至关重要地依赖于这两种细胞类型之间受控的双向对话。在雪旺细胞的生命中可以区分几个主要阶段：决定，分化和潜在的髓鞘形成。本文综述了许旺细胞从多能神经嵴细胞向分化的许旺细胞发育的分子和细胞学特征。
Abstract Schwann cells are the major glial population of the vertebrate peripheral nervous system. In the adult, they build a protecting sheath around neuronal processes and myelinate largecaliber axons. Already early in development, Schwann cells and neurons establish close contacts. Later development and the maintenance of peripheral nerves are crucially dependent on the controlled bidirectional dialogue between these two cell types. Several major phases can be distinguished in the life of a Schwann cell: determination, differentiation, and potentially myelination. The aim of this review is to summarize the molecular and cellular characteristics of the first steps in the life of a Schwann cell, the development from a multipotent neural crest cell to a differentiated Schwann cell.