Relatively high mortality risk in elderly Swedish subjects with low selenium status.
Relatively high mortality risk in elderly Swedish subjects with low selenium status.
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DOI：
10.1038/ejcn.2015.92
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发表时间：
2016-01
影响因子：
4.7
通讯作者：
Aaseth J
中科院分区：
文献类型：
--
作者：
Alehagen U;Johansson P;Björnstedt M;Rosén A;Post C;Aaseth J
尽管开展了数十年的营养信息宣传活动，但瑞典人每日膳食中必需微量元素硒（Se）的摄入量仍然很低，而且其对公众健康的影响目前尚不清楚。本研究的目的是确定瑞典老年人群的血清硒水平，并分析低硒状态是否对死亡率有任何影响。六百六十八（n=668）老年参与者被邀请从一个城市，并在一项观察性研究进行评估。个体被跟踪了6.8年，并在48个月后重新评估了98个个体的硒水平。所有患者的临床检查包括功能分级、超声心动图、心电图和血清硒测定。登记所有死亡率，并通过Kaplan-Meier图评估死亡率终点，计算校正潜在混杂因素的考克斯比例风险比。研究人群（n=668）的平均血清硒水平为67.1 μg/l，相当于相对低的硒摄入量。在调整男性性别、吸烟、缺血性心脏病、糖尿病、慢性阻塞性肺病和心功能受损后，血清硒处于最低四分位数的人的全因和心血管死亡风险分别增加43%（95%CI：1.02-2.00）和56%（95%CI：1.03-2.36）。该结果不是由炎症对血清中硒浓度的影响驱动的。瑞典老年人群的平均血清硒浓度为67.1 μg/l，低于几种硒蛋白酶的生理饱和水平。这一结果可能表明，为了改善瑞典人口的健康，适度补充硒的价值。
The daily dietary intake of selenium (Se), an essential trace element, is still low in Sweden in spite of decades of nutritional information campaigns and the effect of this on the public health is presently not well known. The objective of this study was to determine the serum Se levels in an elderly Swedish population and to analyze whether a low Se status had any influence on mortality. Six-hundred sixty-eight (n=668) elderly participants were invited from a municipality and evaluated in an observational study. Individuals were followed for 6.8 years and Se levels were re-evaluated in 98 individuals after 48 months. Clinical examination of all individuals included functional classification, echocardiography, electrocardiogram and serum Se measurement. All mortality was registered and endpoints of mortality were assessed by Kaplan–Meier plots, and Cox proportional hazard ratios adjusted for potential confounding factors were calculated. The mean serum Se level of the study population (n=668) was 67.1 μg/l, corresponding to relatively low Se intake. After adjustment for male gender, smoking, ischemic heart disease, diabetes, chronic obstructive pulmonary disease and impaired heart function, persons with serum Se in the lowest quartile had 43% (95% confidence interval (CI): 1.02–2.00) and 56% (95% CI: 1.03–2.36) increased risk for all-cause and cardiovascular mortality, respectively. The result was not driven by inflammatory effects on Se concentration in serum. The mean serum Se concentration in an elderly Swedish population was 67.1 μg/l, which is below the physiological saturation level for several selenoprotein enzymes. This result may suggest the value of modest Se supplementation in order to improve the health of the Swedish population.