Brain structure anomalies in autism spectrum disorder--a meta-analysis of VBM studies using anatomic likelihood estimation.
Brain structure anomalies in autism spectrum disorder--a meta-analysis of VBM studies using anatomic likelihood estimation.
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DOI：
10.1002/hbm.21299
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发表时间：
2012-06
影响因子：
4.8
通讯作者：
Eickhoff SB
中科院分区：
文献类型：
--
作者：
Nickl-Jockschat T;Habel U;Michel TM;Manning J;Laird AR;Fox PT;Schneider F;Eickhoff SB
自闭症谱系障碍（ASD）是一种广泛性的发育障碍，具有典型的核心症状，如社会互动障碍、交流异常、重复和刻板行为以及运动技能受损。脑结构的异常被反复假设为在该疾病的发病机制中起主要作用。我们的目的是对目前ASD文献中报道的脑结构变化进行无偏倚的荟萃分析。因此，我们通过Pubmed查询和文献综述对形态学研究进行了全面检索。我们使用了激活似然估计（ALE）方法的修订版本，对神经影像学结果进行基于坐标的荟萃分析。应用概率细胞结构图来比较所获得的显著效果与组织学区域的定位。每个显着的ALE集群分别分析年龄对灰色和白色物质密度变化的影响。我们发现了6个显著的会聚簇，表明ASD患者的大脑结构存在紊乱，包括外侧枕叶、中央周围区、内侧颞叶、基底神经节和靠近右顶叶盖。我们的研究首次提供了自闭症谱系障碍文献中报道的大脑结构变化的定量总结。与原始研究的样本量相当小相比，我们的荟萃分析包括277名ASD患者和303名健康对照者的数据。尽管诊断标准和基于体素的形态测定（VBM）方法不同，但这一无偏倚的总结为一致的结构异常提供了证据，但也暗示了VBM结果对患者年龄的依赖性。
Autism spectrum disorders (ASD) are pervasive developmental disorders with characteristic core symptoms such as impairments in social interaction, deviance in communication, repetitive and stereotyped behavior, and impaired motor skills. Anomalies of brain structure have repeatedly been hypothesized to play a major role in the etiopathogenesis of the disorder. Our objective was to perform unbiased meta-analysis on brain structure changes as reported in the current ASD literature. We thus conducted a comprehensive search for morphometric studies by Pubmed query and literature review. We used a revised version of the activation likelihood estimation (ALE) approach for coordinate-based meta-analysis of neuroimaging results. Probabilistic cytoarchitectonic maps were applied to compare the localization of the obtained significant effects to histological areas. Each of the significant ALE clusters was analyzed separately for age effects on gray and white matter density changes. We found six significant clusters of convergence indicating disturbances in the brain structure of ASD patients, including the lateral occipital lobe, the pericentral region, the medial temporal lobe, the basal ganglia, and proximate to the right parietal operculum. Our study provides the first quantitative summary of brain structure changes reported in literature on autism spectrum disorders. In contrast to the rather small sample sizes of the original studies, our meta-analysis encompasses data of 277 ASD patients and 303 healthy controls. This unbiased summary provided evidence for consistent structural abnormalities in spite of heterogeneous diagnostic criteria and voxel-based morphometry (VBM) methodology, but also hinted at a dependency of VBM findings on the age of the patients.