Macular Thickness Measurements with Frequency Domain-OCT for Quantification of Retinal Neural Loss and its Correlation with Cognitive Impairment in Alzheimer's Disease.
Macular Thickness Measurements with Frequency Domain-OCT for Quantification of Retinal Neural Loss and its Correlation with Cognitive Impairment in Alzheimer's Disease.
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DOI：
10.1371/journal.pone.0153830
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发表时间：
2016
期刊：
影响因子：
3.7
通讯作者：
Monteiro ML
中科院分区：
文献类型：
--
作者：
Cunha LP;Lopes LC;Costa-Cunha LV;Costa CF;Pires LA;Almeida AL;Monteiro ML
目的：评价频域光学相干断层扫描(FD-OCT)对阿尔茨海默病(AD)患者视网膜神经损伤的评估价值。我们还验证了AD相关认知损害与黄斑和乳头周围视网膜神经纤维层(RNFL)厚度测量之间存在相关性。对24例(45眼)AD患者和48例(48眼)正常眼进行FD-OCT扫描。计算视乳头周围RNFL、黄斑全层厚度和黄斑内层节段性厚度参数。黄斑内侧参数包括黄斑视网膜神经纤维层(MRNFL)厚度、神经节细胞层(GCL+)+内丛层厚度(GCL++)和视网膜神经纤维层+GCL+厚度(GCL++)。采用简易智力状态检查(MMSE)对所有受试者的认知能力进行评估。对两组进行比较，并验证MMSE评分与FD-OCT测量之间的关系。与对照组相比，AD患者的平均、上、下象限RNFL厚度参数和9个全厚度黄斑测量中除1个以外的所有参数均显著降低。AD眼的节段层、GCL+和GCL++明显减少。大多数FD-OCT参数(尤其是黄斑厚度测量)与MMSE评分之间存在显著相关性。AD组大部分FD-OCT、视乳头周围RNFL和黄斑视网膜内层全厚、节段性参数均低于对照组。此外，神经元丢失，特别是反映在黄斑参数上的，与AD的认知损害有很好的相关性。我们的结果表明，FD-OCT在AD患者的评估和随访中可能是一种潜在的有用的诊断工具。
To evaluate the ability of frequency domain optical coherence tomography (fd-OCT) to estimate retinal neural loss in eyes with Alzheimer’s disease (AD). We also verified the existence of a correlation between AD-related cognitive impairment and macular and peripapillary retinal nerve fiber layer (RNFL) thickness measurements. fd-OCT scans were obtained from 45 eyes of 24 patients with AD and 48 control eyes. Peripapillary RNFL, macular full-thickness and segmented inner macular thickness parameters were calculated. The inner macular parameters included macular retinal nerve fiber layer (mRNFL) thickness, ganglion cell layer (GCL) plus inner plexiform layer thickness (GCL+), and RNFL plus GCL+ thickness (GCL++). The Mini-Mental State Examination (MMSE) was used to assess cognition in all subjects. The two groups were compared and the relationship between MMSE scores and fd-OCT measurements was verified. Average, superior and inferior quadrant RNFL thickness parameters and all but one of the nine full-thickness macular measurements were significantly reduced in AD patients compared to controls. The segmented layers, GCL+ and GCL++ were significantly reduced in AD eyes. A significant correlation was found between most fd-OCT parameters (especially macular thickness measurements) and MMSE scores. Most fd-OCT peripapillary RNFL and macular full-thickness and segmented inner retinal layers parameters were reduced in AD eyes compared to controls. Moreover, neuronal loss, especially as reflected in macular parameters, correlated well with cognitive impairment in AD. Our results suggest that fd-OCT could be a potentially useful diagnostic tool in the evaluation and follow-up of AD patients.