Genomic study of adolescent idiopathic scoliosis in Japan.
Genomic study of adolescent idiopathic scoliosis in Japan.
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DOI：
10.1186/s13013-016-0067-x
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发表时间：
2016
影响因子：
--
通讯作者：
Ikegawa S
中科院分区：
文献类型：
--
作者：
Ikegawa S
青少年特发性脊柱侧凸（AIS）是一种常见疾病。它是一种受遗传和环境因素控制的多因素（多基因）疾病。已经进行了利用连锁和关联分析寻找 AIS 遗传因素的研究，并报道了几种易感基因。本文综述了日本AIS全基因组关联研究的最新进展，并对其未来的任务进行了评论。
Adolescent idiopathic scoliosis (AIS) is a common disease. It is a multi-factorial (polygenic) disease controlled by genetic and environmental factors. Studies searching for genetic factors of AIS using linkage and association analyses have been conducted and several susceptibility genes have been reported. This paper reviews the recent progress in the genome-wide association study of AIS in Japan and comments on its future task.