Calcium orthophosphates (CaPO4): Occurrence and properties
Calcium orthophosphates (CaPO4): Occurrence and properties
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DOI：
10.1016/j.morpho.2017.03.007
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发表时间：
2017-09-01
期刊：
影响因子：
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通讯作者：
Dorozhkin, S. V.
中科院分区：
文献类型：
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作者：
Dorozhkin, S. V.
本综述旨在将读者的注意力引向正磷酸钙（CaPO4）这一重要课题。这类材料对人类具有特殊意义，因为它们代表了哺乳动物主要正常（骨骼、牙齿和鹿角）和病理（由于各种疾病而出现的）钙化组织的无机部分。例如，动脉粥样硬化导致由胆固醇与CaPO4的固体复合物引起的血管阻塞，而龋齿（蛀牙）和骨质疏松症（具有微结构变化的低骨量）分别意味着牙齿和骨骼的部分脱钙，这导致更难溶解和更硬的生物磷灰石被更易溶解和更软的正磷酸氢钙替代。由于与哺乳动物钙化组织的成分相似，CaPO4被广泛用作骨移植目的的生物材料。此外，CaPO4还有许多其他用途。因此，有一个伟大的意义，CaPO4为人类，在本文中，概述了目前的知识在这个问题上提供。(C)2017 Elsevier Masson SAS。All rights reserved.
The present overview is intended to point the readers' attention to the important subject of calcium orthophosphates (CaPO4). This type of materials is of the special significance for the human beings because they represent the inorganic part of major normal (bones, teeth and antlers) and pathological (those appearing due to various diseases) calcified tissues of mammals. For example, atherosclerosis results in blood vessel blockage caused by a solid composite of cholesterol with CaPO4, while dental caries (tooth decay) and osteoporosis (a low bone mass with microarchitectural changes) mean a partial decalcification of teeth and bones, respectively, that results in replacement of a less soluble and harder biological apatite by more soluble and softer calcium hydrogenorthophosphates. Due to the compositional similarities to the calcified tissues of mammals, CaPO4 are widely used as biomaterials for bone grafting purposes. In addition, CaPO4 have many other applications. Thus, there is a great significance of CaPO4 for the humankind and, in this paper, an overview on the current knowledge on this subject is provided. (C) 2017 Elsevier Masson SAS. All rights reserved.