Novel Insights and Therapeutics in Multiple Sclerosis.
Novel Insights and Therapeutics in Multiple Sclerosis.
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DOI：
10.12688/f1000research.6378.1
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Goverman JM
中科院分区：
文献类型：
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作者：
Wagner CA;Goverman JM
过去12年见证了复发-缓解型多发性硬化症新疗法的发展，与以前的疗法相比，这些疗法的疗效有所提高。这些新药中的许多都是通过控制免疫系统的不同方面来针对疾病的炎症阶段。虽然这些新的治疗方法很有希望，但针对进行性多发性硬化症患者的治疗方法的开发仍然是一个重大挑战。我们讨论了可能导致这两种类型多发性硬化症的不同机制，以及这些差异在开发这种使人衰弱的疾病的新治疗靶点方面的意义。
The last twelve years have witnessed the development of new therapies for relapsing-remitting multiple sclerosis that demonstrate increased efficacy relative to previous therapies. Many of these new drugs target the inflammatory phase of disease by manipulating different aspects of the immune system. While these new treatments are promising, the development of therapies for patients with progressive multiple sclerosis remains a significant challenge. We discuss the distinct mechanisms that may contribute to these two types of multiple sclerosis and the implications of these differences in the development of new therapeutic targets for this debilitating disease.