Organocatalytic highly enantioselective synthesis of secondary α-hydroxyphosphonates
Organocatalytic highly enantioselective synthesis of secondary α-hydroxyphosphonates
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DOI：
10.1021/ol062005s
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发表时间：
2006-10-12
期刊：
影响因子：
5.2
通讯作者：
Zhao, Cong-Gui
中科院分区：
文献类型：
--
作者：
Dodda, Rajasekhar;Zhao, Cong-Gui
通过使用容易获得的L-脯氨酰胺作为催化剂，实现了酮和甲酰膦酸二乙酯水合物的第一个有机催化交叉羟醛反应。已合成出具有高对映选择性（高达 > 99% ee）和良好的非对映选择性的仲 r-羟基膦酸酯。
The first organocatalytic cross aldol reaction of ketones and diethyl formylphosphonate hydrate has been realized by using readily available L-prolinamide as the catalyst. Secondary r-hydroxyphosphonates have been synthesized in high enantioselective (up to > 99% ee) and good diastereoselectivity.