Rituximab therapy in autoimmune pulmonary alveolar proteinosis
Rituximab therapy in autoimmune pulmonary alveolar proteinosis
复制标题
DOI：
10.1183/09031936.00160908
复制
发表时间：
2009-06-01
影响因子：
24.3
通讯作者：
Crestani, B.
中科院分区：
文献类型：
--
作者：
Borie, R.;Debray, M-P.;Crestani, B.
特发性肺泡蛋白沉积症被认为是一种可能导致肺功能不全的自身免疫性疾病。然而，类固醇似乎并不有效，治疗标准是全肺灌洗。我们报告了第一例利妥昔单抗成功治疗的病例，该病例解决了肺泡蛋白沉积症的致病机制。
Idiopathic pulmonary alveolar proteinosis is presumed to be an autoimmune disorder that may lead to pulmonary insufficiency. However, steroids do not appear to be effective and the standard of therapy is whole-lung lavage. We report the first case of successful therapy with rituximab, which addresses the pathogenic mechanism of pulmonary alveolar proteinosis.