Astrocytes show reduced support of motor neurons with aging that is accelerated in a rodent model of ALS
Astrocytes show reduced support of motor neurons with aging that is accelerated in a rodent model of ALS
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DOI：
10.1016/j.neurobiolaging.2014.09.020
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发表时间：
2015-02-01
影响因子：
4.2
通讯作者：
Svendsen, Clive N.
中科院分区：
文献类型：
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作者：
Das, Melanie M.;Svendsen, Clive N.
星形胶质细胞在支持运动神经元的健康和疾病中起着至关重要的作用。然而，很少有人试图了解衰老如何影响这种效应。在这里，我们报告说，大鼠星形胶质细胞表现出年龄依赖性衰老表型和显着减少，他们的能力，以支持运动神经元。在家族性肌萎缩侧索硬化症（ALS）过表达突变型超氧化物歧化酶1（SOD1）的啮齿动物模型中，星形胶质细胞获得衰老表型的速率加快，随后它们对运动神经元的支持减少。胶质细胞源性神经营养因子（GDNF）可部分逆转此作用。因此，用产生GDNF的年轻星形胶质细胞取代老化的星形胶质细胞可能对老化的运动神经元和因ALS等疾病而丢失的运动神经元具有显着的存活促进作用。(C)2015 Elsevier Inc. All rights reserved.
Astrocytes play a crucial role in supporting motor neurons in health and disease. However, there have been few attempts to understand how aging may influence this effect. Here, we report that rat astrocytes show an age-dependent senescence phenotype and a significant reduction in their ability to support motor neurons. In a rodent model of familial amyotrophic lateral sclerosis (ALS) overexpressing mutant superoxide dismutase 1 (SOD1), the rate of astrocytes acquiring a senescent phenotype is accelerated and they subsequently provide less support to motor neurons. This can be partially reversed by glial cell lineederived neurotrophic factor (GDNF). Replacing aging astrocytes with young ones producing GDNF may therefore have a significant survival promoting affect on aging motor neurons and those lost through diseases such as ALS. (C) 2015 Elsevier Inc. All rights reserved.