Progressive and fluctuating sensorineural hearing loss in children with asymptomatic congenital cytomegalovirus infection
Progressive and fluctuating sensorineural hearing loss in children with asymptomatic congenital cytomegalovirus infection
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DOI：
10.1016/s0022-3476(97)70248-8
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发表时间：
1997-04-01
影响因子：
5.1
通讯作者：
Pass, RF
中科院分区：
文献类型：
--
作者：
Fowler, KB;McCollister, FP;Pass, RF
目的：目的：了解临床表现不明显的儿童感音神经性听力损失（SNHL）的患病率和时间变化，（无症状的）先天性巨细胞病毒（CMV）感染，其从筛查先天性CMV感染的新生婴儿队列中鉴定。研究人群包括307名有记录的无症状先天性CMV感染的儿童，76名无症状先天性CMV感染儿童的未感染兄弟姐妹，结果：SNHL仅见于先天性CMV感染患儿，无症状先天性CMV感染患儿中有22例（7.2%，95%可信区间为4.5%~ 10.6%）发生SNHL。在听力损失儿童中，听力进一步恶化的发生率为50.0%，首次进展的中位年龄为18个月（范围，2至70个月），迟发型SNHL的发生率为18.2%，发现的中位年龄为27个月（范围，25至62个月）。波动性SNHL记录在22.7%的儿童听力loss.Conclusions：无症状先天性CMV感染可能是SNHL的主要原因在幼儿，听力的持续恶化和延迟发作的SNHL在这些孩子强调需要继续监测他们的听力状况。
Objective: To determine the prevalence and temporal changes of sensorineural hearing loss (SNHL) among children with clinically inapparent (asymptomatic) congenital cytomegalovirus (CMV) infection identified from a cohort of newborn infants screened for congenital CMV infection,Methods: The study population consisted of 307 children with documented asymptomatic congenital CMV infection, 76 uninfected siblings of children with asymptomatic congenital CMV infection, and 201 children whose neonatal screen for congenital CMV infection showed negative results, Audiologic evaluations were completed for all children to determine their hearing status,Results: SNHL occurred only in children with congenital CMV infection, Of the children with asymptomatic congenital CMV infection, 22 (7.2%; 95% confidence interval, 4.5% to 10.6%) had SNHL. Among the children with hearing loss, further deterioration of hearing occurred in 50.0%, with the median age at first progression at 18 months (range, 2 to 70 months), Delayed-onset SNHL was observed in 18.2% of the children, with the median age of detection at 27 months (range, 25 to 62 months). Fluctuating SNHL was documented in 22.7% of the children with hearing loss.Conclusions: Asymptomatic congenital CMV infection is likely a leading cause of SNHL in young children, The continued deterioration of hearing and delayed onset of SNHL in these children emphasizes the need for continued monitoring of their hearing status.