Chloroplast protein import: solve the GTPase riddle for entry
Chloroplast protein import: solve the GTPase riddle for entry
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DOI：
10.1016/j.tcb.2004.05.004
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发表时间：
2004-07-01
影响因子：
19
通讯作者：
Schnell, DJ
中科院分区：
文献类型：
--
作者：
Kessler, F;Schnell, DJ
通往不同细胞器的众多细胞内蛋白质运输途径的保真度取决于底物蛋白的内在靶向信号与将底物递送至适当细胞器的特定受体之间的相互作用。最近针对叶绿体的蛋白质靶向研究提出了一种新机制，其中 GTP 依赖性底物识别与 GTP 驱动的马达耦合，启动蛋白质易位到细胞器中。
The fidelity of the numerous intracellular protein-trafficking pathways to different organelles is dictated by the interactions between the intrinsic targeting signals of substrate proteins and specific receptors that deliver the substrate to the proper organelle. Recent studies of protein targeting to chloroplasts suggest a novel mechanism in which GTP-dependent substrate recognition is coupled to a GTP-driven motor that initiates the translocation of proteins into the organelle.