Echoes of the embryo: using the developmental biology toolkit to study cancer.
Echoes of the embryo: using the developmental biology toolkit to study cancer.
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DOI：
10.1242/dmm.023184
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发表时间：
2016-02
影响因子：
4.3
通讯作者：
Stanger BZ
中科院分区：
文献类型：
--
作者：
Aiello NM;Stanger BZ
胚胎发育的标志是调节——细胞倾向于进入有组织且“行为良好”的结构——而癌症的特点是失调和紊乱。从表面上看，癌症生物学和发育生物学似乎彼此没有什么关系。但如果深入观察，就会发现胚胎和癌症有许多共同的细胞和分子特征。胚胎由单个细胞产生，并经历涉及细胞迁移和细胞间相互作用的快速生长：这些特征在癌症中也可见到。因此，一个多世纪以来用于研究胚胎发生的许多实验工具非常适合研究癌症。本文将回顾胚胎发生和癌症进展之间的相似性，并讨论用于理解胚胎的一些概念和技术现在如何适应于提供对从癌细胞起源到转移的肿瘤发生的深入了解。摘要：本文回顾了胚胎发生和癌症进展之间的相似性，并讨论了如何应用发育生物学的概念和技术来深入了解肿瘤发生的各个方面。
The hallmark of embryonic development is regulation – the tendency for cells to find their way into organized and ‘well behaved’ structures – whereas cancer is characterized by dysregulation and disorder. At face value, cancer biology and developmental biology would thus seem to have little to do with each other. But if one looks beneath the surface, embryos and cancers share a number of cellular and molecular features. Embryos arise from a single cell and undergo rapid growth involving cell migration and cell-cell interactions: features that are also seen in the context of cancer. Consequently, many of the experimental tools that have been used to study embryogenesis for over a century are well-suited to studying cancer. This article will review the similarities between embryogenesis and cancer progression and discuss how some of the concepts and techniques used to understand embryos are now being adapted to provide insight into tumorigenesis, from the origins of cancer cells to metastasis. Summary: This article reviews the similarities between embryogenesis and cancer progression and discusses how the concepts and techniques of developmental biology are being applied to provide insight into all aspects of tumorigenesis.