Specific Vaginal Bacteria Are Associated With an Increased Risk of Trichomonas vaginalis Acquisition in Women.
Specific Vaginal Bacteria Are Associated With an Increased Risk of Trichomonas vaginalis Acquisition in Women.
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特定的阴道细菌与女性感染阴道毛滴虫的风险增加有关。
DOI：
10.1093/infdis/jiz354
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
McClelland,RScott
中科院分区：
文献类型：
--
作者：
Jarrett,OlamideD;Srinivasan,Sujatha;Richardson,BarbraA;Fiedler,Tina;Wallis,JacquelineM;Kinuthia,John;Jaoko,Walter;Mandaliya,Kishor;Fredricks,DavidN;McClelland,RScott
BackgroundWhile细菌性阴道病已与阴道毛滴虫（TV）收购的风险增加，它是未知的，是否阴道微生物群的其他特征，包括关键细菌物种的存在，影响一个女人的风险TV acquisition.MethodsThe阴道微生物群前25个独特的情节电视感染涉及18名妇女进行了比较，50名控制谁仍然未感染。通过转录介导的扩增检测TV。阴道微生物群进行了定量，使用广泛的聚合酶链反应分析和分类特异性定量PCR的16 S核糖体RNA基因。结果电视收购显着相关的存在普氏普雷沃菌（风险比[RR]，2.21; 95%可信区间[CI]，1.12-4.38;P= 0.02）和血红色呼吸道线虫（RR，2.58; 95%CI，1.00-6.62;P= 0.049）。当调整月经期时，P. MRI和TV获取保持相似（调整后的RR，2.11; 95% CI，1.03-4.33;P= 0.04），但S.血吸虫和TV获得减弱（调整后的RR，2.31; 95%CI，0.86 -6.23;P= 0.10）。了解这些细菌物种如何增加女性获得电视的风险可能有助于指导新策略的开发，以降低女性感染电视的风险。
BackgroundWhile bacterial vaginosis has been associated with an increased risk ofTrichomonas vaginalis(TV) acquisition, it is unknown whether other characteristics of the vaginal microbiota, including the presence of key bacterial species, influence a woman’s risk of TV acquisition.MethodsThe vaginal microbiota before 25 unique episodes of TV infection involving 18 women was compared to that of 50 controls who remained uninfected. TV was detected by transcription-mediated amplification. Vaginal microbiota were quantified using broad-range polymerase chain reaction analysis and taxon-specific quantitative PCR of the 16S ribosomal RNA gene.ResultsTV acquisition was significantly associated with the presence ofPrevotella amnii(risk ratio [RR], 2.21; 95% confidence interval [CI], 1.12–4.38;P= .02) andSneathia sanguinegens(RR, 2.58; 95% CI, 1.00–6.62;P= .049). When adjusted for menstrual phase, the association betweenP. amniiand TV acquisition remained similar (adjusted RR, 2.11; 95% CI, 1.03–4.33;P= .04), but the association betweenS. sanguinegensand TV acquisition was attenuated (adjusted RR, 2.31; 95% CI, .86–6.23;P= .10).ConclusionsKey vaginal bacterial species may contribute to the susceptibility to TV acquisition. Understanding how these bacterial species increase a woman’s risk of TV acquisition could help to guide the development of novel strategies to reduce women’s risk of TV infection.
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