Preparation of photodynamic P(MMA-co-MAA) composite nanofibers doped with MMT: A facile method for increasing antimicrobial efficiency
Preparation of photodynamic P(MMA-co-MAA) composite nanofibers doped with MMT: A facile method for increasing antimicrobial efficiency
复制标题
掺杂 MMT 的光动力 P(MMA-co-MAA) 复合纳米纤维的制备：一种提高抗菌效率的简便方法
DOI：
10.1016/j.apsusc.2018.06.041
复制
发表时间：
2018
影响因子：
6.7
通讯作者：
Qufu Wei
中科院分区：
文献类型：
--
作者：
Qingqing Wang;Wangbingfei Chen;Quan Zhang;Reza A Ghiladi;Qufu Wei
本文报道了以蒙脱土（MMT）掺杂P（MMA-co-MAA）共聚物电纺纳米纤维，并进一步用阳离子光敏剂亚甲基蓝（MB）进行功能化，制备光动力材料。所得复合纳米纤维的特征在于光谱（红外，紫外维斯，荧光）和物理（SEM/TEM，重量分析）方法。在静电纺丝过程中加入0- 6wt%的MMT，使P（MMA-co-MAA）/MMT-6复合纳米纤维对亚甲基蓝光敏剂的吸附量从21.5mg（67.1 μmol）/g P（MMA-co-MAA）提高到30.0mg（93.8 μmol）/g P（MMA-co-MAA）/MMT-6复合纳米纤维。MB修饰的P（MMA-co-MAA）/MMT-6复合纳米纤维的拉伸强度为99.997%，（4.8个对数单位）和97%针对金黄色葡萄球菌的CFU/mL降低（1.8 log单位）（ATCC-6538）和大肠杆菌菌株8099，在可见光照射后（LED灯，30 min，35 ± 5 mW/cm 2），这表明归因于MMT掺杂的增加的光敏剂负载导致光动力学失活功效比未掺杂的MB修饰的P（MMA-共-MAA）母体共聚物（对于S. aureusandE. coli）。结果表明，MMT和类似的添加剂可能是一种通用的方法，用于增加阳离子光敏剂在电纺纳米纤维中的吸附能力，从而产生具有改善的光动力灭活功效的材料，而不会显着改变纤维形态，成本或易于生产。
We report the preparation of photodynamic materials from electrospun nanofibers of P(MMA-co-MAA) co-polymer that were doped with montmorillonite (MMT), and further functionalized with the cationic photosensitizer methylene blue (MB). The resultant composite nanofibers were characterized by spectroscopic (infrared, UV − vis, fluorescence) and physical (SEM/TEM, gravimetric) methods. Addition of MMT (0–6 wt%) in the electrospinning process increased the adsorption of the methylene blue photosensitizer from 21.5 mg (67.1 μmol)/g P(MMA-co-MAA) parent copolymer to 30.0 mg (93.8 μmol)/g P(MMA-co-MAA)/MMT-6 composite nanofibers. The MB-decorated P(MMA-co-MAA)/MMT-6 composite nanofibers showed a 99.997% (4.8 log units) and 97% (1.8 log units) reduction in CFU/mL againstStaphylococcus aureus(ATCC-6538) andEscherichia colistrain 8099, respectively, after visible light illumination (LED lamp, 30 min, 35 ± 5 mW/cm2), demonstrating that the increased photosensitizer loading attributable to MMT doping led to a 1–2 log unit increase in photodynamic inactivation efficacy over the non-doped MB-decorated P(MMA-co-MAA) parent copolymer (99.9% and 84% reduction forS. aureusandE. coli, respectively). The results demonstrate that MMT and similar additives may be a universal method for increasing the adsorption capacity of cationic photosensitizers in electrospun nanofibers, thereby generating materials with improved photodynamic inactivation efficacy without significantly changing the fiber morphology, cost, or ease of production.