Hedonic and Informational Functions of the Human Orbitofrontal Cortex
Hedonic and Informational Functions of the Human Orbitofrontal Cortex
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DOI：
10.1093/cercor/bhp092
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发表时间：
2010-01-01
期刊：
影响因子：
3.7
通讯作者：
Deakin, J. F. W.
中科院分区：
文献类型：
--
作者：
Elliott, R.;Agnew, Z.;Deakin, J. F. W.
功能成像研究揭示了眶额皮质（OFC）在奖励加工和决策中的作用。在许多情况下，奖励暗示当前的行为应该保持，而惩罚暗示行为的改变。因此，对强化物的享乐反应与它们作为行为线索的功能相结合。为了消除这些功能的歧义，我们对一个2选择决策任务进行了功能性磁共振成像研究。每次试验结束后，受试者都会受到奖励或惩罚，并独立地提供维持或改变行为的线索。我们确定了参与这些过程的OFC的关键区域。前内侧病灶对奖励有反应，而双侧外侧病灶对惩罚有反应。对惩罚做出反应的右侧外侧区域也对行为改变（转移）的提示做出反应，而更侧腹和前部的双侧区域对行为维持（停留）的提示做出反应。当停留提示与惩罚相结合时，右侧停留区会做出特别的反应。这些结果支持了OFC编码对强化物的享乐反应及其行为后果的观点。惩罚和转移线索与相同的右侧OFC焦点有关，这表明对负强化的情绪反应与使用负面信息提示行为改变之间存在根本联系。
Functional imaging studies have revealed roles for orbitofrontal cortex (OFC) in reward processing and decision making. In many situations, rewards signal that the current behavior should be maintained, whereas punishments cue a change in behavior. Thus, hedonic responses to reinforcers are conflated with their function as behavioral cues. In an attempt to disambiguate these functions, we performed a functional magnetic resonance imaging study of a 2-choice decision-making task. After each trial, subjects were rewarded or punished and independently provided with a cue to maintain or change behavior. We identified key regions of OFC involved in these processes. An anterior medial focus responded to reward, whereas bilateral lateral foci responded to punishment. The right-sided lateral region that responded to punishment also responded to cues for behavior change (shift), whereas a more ventral and anterior bilateral region responded to cues for behavioral maintenance (stay). The right-sided stay region responded specifically when stay cues were combined with punishment. These results support the view that OFC codes both hedonic responses to reinforcers and their behavioral consequences. Punishments and shift cues are associated with the same right lateral OFC focus, suggesting a fundamental connection between emotive response to negative reinforcement and use of negative information to cue behavioral change.