International consensus statement on preliminary classification criteria for definite antiphospholipid syndrome - Report of an international workshop
International consensus statement on preliminary classification criteria for definite antiphospholipid syndrome - Report of an international workshop
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DOI：
10.1002/1529-0131(199907)42:7
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发表时间：
1999-07-01
影响因子：
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通讯作者：
Khamashta, MA
中科院分区：
文献类型：
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作者：
Wilson, WA;Gharavi, AE;Khamashta, MA
抗磷脂综合征（APS）的初步分类标准是在第八届国际抗磷脂抗体研讨会之后于 1998 年 10 月 10 日在日本札幌举行的会后研讨会上制定的。研讨会小组成员包括所有作者和附录中列出的个人。人们对抗磷脂抗体 (aPL) 临床重要性的广泛认识始于 Harris、Gharavi 及其同事 1983 年的开创性工作 (1)。札幌研讨会和 1996 年举行的第七届国际抗磷脂抗体研讨会 (2-11) 审查的临床和实验证据表明，aPL 与血管血栓和流产显着相关，并可能在其中起因果作用。然而，这种关联发生的机制尚不清楚，并且似乎是异质性的，这在一定程度上反映了 aPL 抗体的异质性。临床和基础科学学科的多样性对 APS 知识做出了重大贡献，因此更加需要制定 APS 共识标准；这些包括风湿病学、免疫学、产科、神经病学、血液学、放射学、蛋白质和脂质化学以及分子生物学。尽管之前有 4 项标准提案 (12-16)，但该领域的研究人员仍然普遍认为 APS 分类需要统一和共识。自1984年以来，每两年举办一次抗磷脂抗体国际多学科研讨会(17)。最近的每场研讨会都有超过 250 名注册者参加，每场研讨会都会提交 250-300 份摘要。 56 名研究者参加了在札幌举行的关于分类标准的会后研讨会，其中包括 27 名研讨会顾问委员会成员。十八位该领域公认的专家研究员做了特邀报告，
Preliminary classification criteria for the antiphospholipid syndrome (APS) were formulated during a post-conference workshop held October 10, 1998 in Sapporo, Japan, following the Eighth International Symposium on Antiphospholipid Antibodies. Members of the workshop panel included all of the authors and the individuals listed in the Appendix. Widespread recognition of the clinical importance of antiphospholipid antibodies (aPL) dates from the seminal work of Harris, Gharavi, and their colleagues in 1983 (1). Clinical and experimental evidence, reviewed at the Sapporo symposium and at the Seventh International Symposium on Antiphospholipid Antibodies held in 1996 (2–11), indicates that aPL are significantly associated with and may have a causative role in vascular thromboses and pregnancy losses. However, the mechanisms by which the associations occur are not well understood and appear to be heterogeneous, reflecting, in part, the heterogeneity of aPL antibodies. The need to develop consensus criteria for APS has been heightened by the diversity of clinical and basic science disciplines that have made major contributions to knowledge of APS; these include rheumatology, immunology, obstetrics, neurology, hematology, radiology, protein and lipid chemistry, and molecular biology. Notwithstanding 4 previous proposals for criteria (12–16), there remains a wide perception among investigators in the field that there is a need for uniformity and consensus in classifying APS. An international multidisciplinary symposium on antiphospholipid antibodies has been held every 2 years since 1984 (17). Recent symposia have each been attended by more than 250 registrants, and at each symposium 250–300 abstracts have been presented. The post-symposium workshop on classification criteria in Sapporo was attended by 56 investigators, including 27 members of the advisory board of the symposium. Eighteen investigators who are acknowledged experts in the field made invited presentations,