Incidence of medically attended influenza infection and cases averted by vaccination, 2011/2012 and 2012/2013 influenza seasons
Incidence of medically attended influenza infection and cases averted by vaccination, 2011/2012 and 2012/2013 influenza seasons
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DOI：
10.1016/j.vaccine.2015.07.098
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发表时间：
2015-09-22
期刊：
影响因子：
5.5
通讯作者：
Thompson, Mark G.
中科院分区：
文献类型：
--
作者：
Jackson, Michael L.;Jackson, Lisa A.;Thompson, Mark G.
背景资料：我们估计门诊流感的负担和预防接种疫苗的情况下，在2011/2012年和2012/2013年流感季节使用的数据从美国流感疫苗有效性（US Flu VE）Network.Methods：我们定义的人谁可以寻求治疗急性呼吸道疾病（ARI）在每个美国流感VE网络站点的源人群。我们确定了在US Flu VE流感监测期间接受流感检测的所有来源人群成员。每例流感阳性受试者接受的采样权重基于接受流感检测的源人群成员比例，并按研究中心、年龄和其他因素分层。我们使用抽样权重来估计源人群中接受医疗护理的流感的累积发病率。我们估计的情况下，通过接种疫苗避免使用估计的累积发病率，疫苗覆盖率，和疫苗effectiveness.Results：医疗参加流感的累积发病率范围从0.8%到2.8%，在2011/2012年期间，从2.6%到2012/2013年期间，从2.6%到6.5%。按年龄分层，发病率范围从2011/2012年50岁及以上成人的1.2%到2012/2013年6个月至8岁儿童的10.9%。避免接种疫苗的情况下，范围从4至41每1000名接种者，根据研究地点和year.Conclusions：医疗参加流感的发病率有很大的不同，每年，甚至在同一年内的地理区域。通过接种疫苗避免的病例数因总体发病率和疫苗覆盖率而有很大差异。(C)2015爱思唯尔有限公司版权所有。
Background: We estimated the burden of outpatient influenza and cases prevented by vaccination during the 2011/2012 and 2012/2013 influenza seasons using data from the United States Influenza Vaccine Effectiveness (US Flu VE) Network.Methods: We defined source populations of persons who could seek care for acute respiratory illness (ARI) at each of the five US Flu VE Network sites. We identified all members of the source population who were tested for influenza during US Flu VE influenza surveillance. Each influenza-positive subject received a sampling weight based on the proportion of source population members who were tested for influenza, stratified by site, age, and other factors. We used the sampling weights to estimate the cumulative incidence of medically attended influenza in the source populations. We estimated cases averted by vaccination using estimates of cumulative incidence, vaccine coverage, and vaccine effectiveness.Results: Cumulative incidence of medically attended influenza ranged from 0.8% to 2.8% across sites during 2011/2012 and from 2.6% to 6.5% during the 2012/2013 season. Stratified by age, incidence ranged from 1.2% among adults 50 years of age and older in 2011/2012 to 10.9% among children 6 months to 8 years of age in 2012/2013. Cases averted by vaccination ranged from 4 to 41 per 1000 vaccinees, depending on the study site and year.Conclusions: The incidence of medically attended influenza varies greatly by year and even by geographic region within the same year. The number of cases averted by vaccination varies greatly based on overall incidence and on vaccine coverage. (C) 2015 Elsevier Ltd. All rights reserved.