Neural Mechanisms of Versatile Functions in Primate Anterior Cingulate Cortex
Neural Mechanisms of Versatile Functions in Primate Anterior Cingulate Cortex
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DOI：
10.1515/revneuro.2004.15.4.279
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发表时间：
2004
影响因子：
4.1
通讯作者：
Y. Isomura;Masahiko Takada
中科院分区：
文献类型：
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作者：
Y. Isomura;Masahiko Takada
前扣带皮层（ACC）位于人类和非人类灵长类动物大脑半球的内侧壁，具有发达的皮层内和皮层下连接。最近的脑成像研究表明，ACC可能参与多种认知和运动相关功能。为了阐明ACC高阶功能背后的细胞机制，在执行特定任务的猴子中，通过单单元记录，研究了ACC不同区域及其相邻扣带区的神经元活动。每个吻侧（CMAr）、背侧（CMAd）和腹侧（CMAv）扣带运动区基本上都参与运动相关的功能，如运动的准备和执行。特别是，CMAr似乎与选择适当的运动反应以及计划连续运动有关。此外，CMAr和32区可能参与选择正确动作所必需的注意功能。这些领域还涉及到错误操作的检测和/或操作性能的监控。最后，ACC中的一些神经元表现出与奖励预期相关的特定或调节活动。灵长类动物的前扣带皮层可能在执行适当的注意行为和检查表现以有效获得奖励方面发挥关键作用。
The anterior cingulate cortex (ACC) is located on the medial wall of the cerebral hemisphere in humans and non-human primates, and has well developed intracortical and subcortical connections. Recent brain-imaging studies have suggested the possible involvement of the ACC in a variety of cognitive and motor-related functions. To clarify the cellular mechanisms underlying such higher-order functions in the ACC, neuronal activity in distinct areas of the ACC and its adjacent cingulate areas has been examined, through single unit recordings, in monkeys performing specific tasks. Each of the rostral (CMAr), dorsal (CMAd), and ventral (CMAv) cingulate motor areas basically participates in motor-related functions such as preparation and execution of movements. In particular, the CMAr appears to be involved in selection of appropriate motor responses as well as in planning of sequential movements. Furthermore, the CMAr and area 32 may participate in attentional functions which are necessary to select correct actions. These areas have also been implicated in detection of error actions and/or monitoring of action performance. Finally, a number of neurons in the ACC exhibit specific or modulated activity relevant to reward expectation. The primate ACC may play critical roles in performing appropriate actions with attention and in checking the performance to acquire rewards efficiently.