DS-1, A MODIFIED QUILLAJA SAPONIN, ENHANCES OCULAR AND NASAL ABSORPTION OF INSULIN
DS-1, A MODIFIED QUILLAJA SAPONIN, ENHANCES OCULAR AND NASAL ABSORPTION OF INSULIN
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DOI：
10.1002/jps.2600841104
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发表时间：
1995-11-01
影响因子：
3.8
通讯作者：
KENSIL, CR
中科院分区：
文献类型：
--
作者：
PILLION, DJ;RECCHIA, J;KENSIL, CR
The purpose of this study was to test DS-1, a modified Quillaja saponin, for its efficacy as an absorption enhancer. Anesthetized rats receiving eyedrops or nosedrops formulated with regular pork insulin in saline showed no hypoglycemic response, indicating no systemic absorption of insulin. However, rats receiving eyedrops or nosedrops formulated with insulin plus 0.025-0.10% DS-1 showed rapid absorption of insulin and a concomitant decrease in serum D-glucose levels. No response was observed following sublingual or buccal delivery of insulin. In conclusion, the modified saponin DS-1 was efficacious at enhancing nasal or ocular insulin delivery at extremely low concentrations. The mechanism of DS-1 action is not yet known.
