Improved survival in both histologic types of oesophageal cancer in Sweden
Improved survival in both histologic types of oesophageal cancer in Sweden
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DOI：
10.1002/ijc.10420
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发表时间：
2002-06-10
影响因子：
6.4
通讯作者：
Lagergren, J
中科院分区：
文献类型：
--
作者：
Sundelöf, M;Ye, WM;Lagergren, J
在大多数国家，诊断为食管癌的患者的预后很差，总的5年生存率接近5%。然而，改进的诊断和手术策略可能会影响生存率。我们调查了1961-1996年瑞典所有诊断为食管腺癌（n = 1，441）或鳞状细胞癌（n = 6395）的患者的观察生存率和相对生存率，并随访至1997年12月。观察到的生存率计算寿命表法。相对存活率计算为观察到的存活率与预期存活率的比值。预期生存率是根据相同年龄、性别和日历年分层的整个瑞典人群的生存率推断的。腺癌的5年观察生存率从1961-1989年期间接近4%的稳定数字增加到1990-1996年期间的10.5%。类似地，5年相对存活率在1961-1989年期间稳定在5%左右，但在1990-1996年期间存活率增加到13.7%。对于鳞状细胞癌，生存率每十年略有改善，从1961-1969年的3.8% 5年观察生存率到1990-1996年的7.0%。同样，研究期间5年相对生存率从5.0%提高到8.9%。总之，与前30年相比，20世纪90年代食管腺癌和鳞状细胞癌的生存率显著增加（p < 0.001）。(C)2002 Wiley-Liss，Inc.
The prognosis among patients diagnosed with oesophageal cancer is poor with an overall 5-year survival close to 5% in most countries. Improved diagnostic and surgical strategies might influence the survival, however. We investigated the observed and relative survival among all patients in Sweden diagnosed with oesophageal adenocarcinoma (n = 1,441) or squamous cell carcinoma (n = 6395) from 1961-1996 with follow-up to December 1997. Observed survival rates were calculated by the life-table method. Relative survival rates were computed as the ratio of the observed to the expected survival. The expected survival was inferred from the survival among the entire Swedish population in the same age, sex and calendar year strata. The 5-year observed survival rate for adenocarcinoma increased from a stable figure close to 4% during the entire period 1961-1989 to 10.5% during 1990-1996. Similarly, the 5-year relative survival rate was stable around 5% during 1961-1989, but during 1990-1996 the survival was increased to 13.7%. For squamous cell carcinoma, the survival improved slightly by each decade, starting with 3.8% 5-year observed survival in 1961-1969 to 7.0% during 1990-1996. Similarly, the 5-year relative survival improved from 5.0% to 8.9% during the study period. In conclusion, the survival rates for both oesophageal adenocarcinoma and squamous cell carcinoma have increased significantly during the 1990s compared to those in the previous 3 decades (p < 0.001). (C) 2002 Wiley-Liss, Inc.