Self-disinfecting and Microbiocide-Impregnated Surfaces and Fabrics: What Potential in Interrupting the Spread of Healthcare-Associated Infection?
Self-disinfecting and Microbiocide-Impregnated Surfaces and Fabrics: What Potential in Interrupting the Spread of Healthcare-Associated Infection?
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DOI：
10.1093/cid/cit765
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发表时间：
2014-03-15
影响因子：
11.8
通讯作者：
Humphreys, Hilary
中科院分区：
文献类型：
--
作者：
Humphreys, Hilary
创新技术已经确定了开发自消毒表面或织物的方法，以最大限度地减少医疗相关感染（HCAI）。这些包括改变结构或表面以最小化微生物的附着或延迟生物膜的发展，使用在光存在下活化的化合物以减少微生物负荷，以及掺入具有固有抗微生物活性的重金属如银或铜。大多数用于表面和织物的技术已经在体外进行了评估，并已显示出将细菌数量减少>= 2个对数。然而，除了铜浸渍表面，很少有临床试验。与对照组相比，铜浸渍表面导致临床领域常见表面上的微生物表面计数减少，1项研究评估了HCAI和定植率。然而，需要更大规模和更好设计的研究来确定这些方法是否能增强当前的卫生方案，特别是当这些方法得到最佳实施时。
Innovative technologies have identified approaches to developing self-disinfecting surfaces or fabrics to minimize healthcare-associated infection (HCAI). These include altering the structure or surface to minimize the attachment of microbes or to delay the development of biofilm, using compounds that are activated in the presence of light to reduce the microbial burden, and incorporating a heavy metal such as silver or copper with intrinsic antimicrobial activity. Most technologies for surfaces and fabrics have been assessed in vitro and have been shown to reduce bacterial numbers by >= 2 logs. However, apart from copper -impregnated surfaces, there have been few trials in a clinical setting. Copper-impregnated surfaces result in reduced microbial surface counts on surfaces commonly found in clinical areas compared with controls, and 1 study has assessed HCAI and colonization rates. However, larger and better-designed studies are required to determine if these approaches augment current hygiene regimens, especially when these are optimally implemented.