Recent approaches for targeted drug delivery in rheumatoid arthritis diagnosis and treatment
Recent approaches for targeted drug delivery in rheumatoid arthritis diagnosis and treatment
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DOI：
10.1080/21691401.2018.1460373
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发表时间：
2018-01-01
影响因子：
5.8
通讯作者：
Taymouri, Somayeh
中科院分区：
文献类型：
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作者：
Chegini, Sana Pirmardvand;Varshosaz, Jaleh;Taymouri, Somayeh
类风湿关节炎(RA)是一种慢性炎症性疾病，病理复杂，以关节炎症、滑膜破坏、血管疙瘩形成、骨和软骨破坏为特征，常伴有持续性关节炎疼痛、肿胀、僵硬和工作障碍。在传统的RA治疗中，由于生物半衰期短，生物利用度低，需要高而频繁的剂量。因此，这些抗RA药物不能选择性地针对受影响的区域，可能会对关节外组织造成严重的副作用。今天，纳米技术已经成为开发用于治疗和诊断类风湿性关节炎等顽固性疾病的新型药物输送系统的有前途的工具。RA纳米药物中的主动靶向也是一种成功的方法，可以促进疾病细胞对治疗剂的特定摄取。在这篇综述中，试图描述用于RA诊断和治疗的各种靶向给药系统(局部的和基于受体的)。然后，我们重点介绍了用于RA基因治疗的各种非病毒基因递送系统的最新进展
Rheumatoid arthritis (RA) is a chronic inflammatory disease with complex pathology characterized by inflammation of joints, devastation of the synovium, pannus formation, bones and cartilage destruction and often is associated with persistent arthritic pain, swelling, stiffness and work disability. In conventional RA therapy, because of short biological half-life, poor bioavailability, high and frequent dosing is required. Thereby, these anti-RA medications, which unable to selectively target affected zone, may cause severe side effects in extra-articular tissues. Today, nanotechnology has emerged as promising tool in the development of novel drug delivery systems for the treatment and diagnosis of intractable diseases such as RA. Active targeting in RA nanomedicine has also been introduced a successful way for facilitating specific uptake of therapeutic agents by the disease cells. In this review, it is attempted to describe various targeted drug delivery systems (localized and receptor-based) used for RA diagnosis and therapy. Then, we highlight recent developments related to various non-viral gene delivery systems for RA gene therapy