Dynamic statistical parametric mapping: Combining fMRI and MEG for high-resolution imaging of cortical activity
Dynamic statistical parametric mapping: Combining fMRI and MEG for high-resolution imaging of cortical activity
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DOI：
10.1016/s0896-6273(00)81138-1
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发表时间：
2000-04-01
期刊：
影响因子：
16.2
通讯作者：
Halgren, E
中科院分区：
文献类型：
--
作者：
Dale, AM;Liu, AK;Halgren, E
功能性磁共振成像（fMRI）可以提供毫米空间分辨率的大脑激活图，但其时间分辨率仅限于秒级。在这里，我们描述了一种技术，结合结构和功能磁共振成像与脑磁图（MEG），以获得具有毫秒时间分辨率的人脑活动的时空图。这种新技术被用来获得动态统计参数地图的皮层活动在语义处理的视觉呈现的话。最初的一波活动被发现迅速蔓延，从枕叶视觉皮层的颞，顶叶和额叶区在185毫秒内，不同地区之间的高度重叠的时间。重复效应被观察到在许多相同的领域后，这一初始波的激活，提供证据的参与反馈机制在重复启动。
Functional magnetic resonance imaging (fMRI) can provide maps of brain activation with millimeter spatial resolution but is limited in its temporal resolution to the order of seconds. Here, we describe a technique that combines structural and functional MRI with magnetoencephalography (MEG) to obtain spatiotemporal maps of human brain activity with millisecond temporal resolution. This new technique was used to obtain dynamic statistical parametric maps of cortical activity during semantic processing of visually presented words. An initial wave of activity was found to spread rapidly from occipital visual cortex to temporal, parietal, and frontal areas within 185 ms, with a high degree of temporal overlap between different areas. Repetition effects were observed in many of the same areas following this initial wave of activation, providing evidence for the involvement of feedback mechanisms in repetition priming.