Potential therapeutic mechanism of traditional Chinese medicine monomers on neurological recovery after spinal cord injury.
Potential therapeutic mechanism of traditional Chinese medicine monomers on neurological recovery after spinal cord injury.
复制标题
中药单体对脊髓损伤后神经功能恢复的潜在治疗机制
DOI：
10.1097/cm9.0000000000001476
复制
发表时间：
2021-04-28
影响因子：
6.1
通讯作者：
Lyu CL
中科院分区：
文献类型：
--
作者：
Zhang T;Gao K;Yan TZ;Lyu CW;Lyu CL
近年来，随着中医药文化的发展和崛起，中药单体研究已成为研究中药抗病机制的主要方法。近年来的研究表明，雷公藤甲素、姜黄素、人参皂苷等多种中药单体在SCI大鼠的治疗中发挥着重要作用。本研究总结了与SCI后炎症反应、细胞凋亡、神经元自噬、氧化应激和神经再生相关的中药单体，并解释了各中药单体的具体分子机制。结合前期实验结果，我们总结出：（1）中药单体通过Wnt/b-catenin/NF-kB信号通路抑制SCI大鼠炎症反应的发生和发展；（2）Wnt/b-catenin/NF-kB信号通路调节的神经元炎症反应对SCI大鼠神经功能恢复具有保护作用[图1]。这一创新假说为SCI后相关中药单体的应用提供了新的分子机制。
In recent years, with the development and rise of Chinese medicine culture, TCM monomer research has become the main method to study the disease resistance mechanism of TCM. Recent studies have shown that multiple TCM monomers, such as triptolide, curcumin, and ginsenoside, play important roles in the treatment of SCI rats. In the present study, we summarized the TCMmonomers related to inflammatory response, apoptosis, neuronal autophagy, oxidative stress, and nerve regeneration after SCI and explained the specific molecular mechanism of each TCM monomer. Combined with the results of our previous experiments, we summarized that (1) TCM monomers inhibit the occurrence and development of inflammatory reactions through the Wnt/b-catenin/nuclear factor-kappa B (NF-kB) signaling pathway in SCI rats and (2) the neuronal inflammatory response regulated by the Wnt/ b-catenin/NF-kB signaling pathway has a protective effect on neural function recovery in SCI rats [Figure 1]. This innovative hypothesis provides a newmolecularmechanism for the application of related TCM monomers after SCI.