Small animal radiation research platform: imaging, mechanics, control and calibration.
Small animal radiation research platform: imaging, mechanics, control and calibration.
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小动物辐射研究平台：成像、力学、控制和校准。
DOI：
10.1007/978-3-540-75759-7_112
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发表时间：
2007
期刊：
影响因子：
--
通讯作者：
Kazanzides,Peter
中科院分区：
文献类型：
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作者：
Matinfar,Mohammad;Gray,Owen;Iordachita,Iulian;Kennedy,Chris;Ford,Eric;Wong,John;Taylor,RussellH;Kazanzides,Peter
在癌症研究中，具有良好特性的人类癌症小动物模型，如转基因小鼠，极大地加快了癌症治疗的发展步伐。小动物辐射研究平台(SARRP)的目标是使这些相同的模型可用于开发和评估新型放射疗法。结合先进的成像方法，小动物研究可以对生物过程、疾病进展和治疗反应进行详细研究，有可能为临床环境提供一座天然的桥梁。SARRP将在标准动物模型中真实地模拟人类放射治疗方法。本文描述了该系统的机械结构和控制结构。本文详细介绍了该系统在成像和放射治疗中对X射线束进行精确定标的要求。
In cancer research, well characterized small animal models of human cancer, such as transgenic mice, have greatly accelerated the pace of development of cancer treatments. The goal of the Small Animal Radiation Research Platform (SARRP) is to make those same models available for the development and evaluation of novel radiation therapies. In combination with advanced imaging methods, small animal research allows detailed study of biological processes, disease progression, and response to therapy, with the potential to provide a natural bridge to the clinical environment. The SARRP will realistically model human radiation treatment methods in standard animal models. In this paper, we describe the mechanical and control structure of the system. This system requires accurate calibration of the x-ray beam for both imaging and radiation treatment, which is presented in detail in the paper.