Lateral Preoptic Control of the Lateral Habenula through Convergent Glutamate and GABA Transmission
Lateral Preoptic Control of the Lateral Habenula through Convergent Glutamate and GABA Transmission
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DOI：
10.1016/j.celrep.2017.10.066
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发表时间：
2017-11-14
期刊：
影响因子：
8.8
通讯作者：
Morales, Marisela
中科院分区：
文献类型：
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作者：
Barker, David J.;Miranda-Barrientos, Jorge;Morales, Marisela
外侧缰核（LHb）是一种参与认知和情绪处理的大脑结构，与多种精神障碍有关。虽然LHb的最大输入来源于外侧视前区（LPO），但对LPO如何参与LHb功能的调节知之甚少。在这里，我们提供的证据表明，LPO施加二价控制LHb通过会聚传输的LPO谷氨酸和γ-氨基丁酸（GABA）到单个LHb神经元。在体内，LHb的LPO-GABA能和LPO-GABA能输入都被厌恶性刺激激活，当独立刺激时，它们的预测线索还产生相反的行为。这些结果支持这样一种模型，其中会聚的LPO-谷氨酸和LPO-GABA的平衡反应对于对伤害性刺激的正常反应是必要的，并且LPO -> LHb谷氨酸或GABA的不平衡导致可能是精神障碍的基础的异常处理的类型。
The lateral habenula (LHb) is a brain structure that participates in cognitive and emotional processing and has been implicated in several mental disorders. Although one of the largest inputs to the LHb originates in the lateral preoptic area (LPO), little is known about how the LPO participates in the regulation of LHb function. Here, we provide evidence that the LPO exerts bivalent control over the LHb through the convergent transmission of LPO glutamate and gamma-aminobutyric acid (GABA) onto single LHb neurons. In vivo, both LPO-glutamatergic and LPO-GABAergic inputs to the LHb are activated by aversive stimuli, and their predictive cues yet produce opposing behaviors when stimulated independently. These results support a model wherein the balanced response of converging LPO-glutamate and LPO-GABA are necessary for a normal response to noxious stimuli, and an imbalance in LPO -> LHb glutamate or GABA results in the type of aberrant processing that may underlie mental disorders.