Mitochondrial haplogroup X is associated with successful aging in the Amish.
Mitochondrial haplogroup X is associated with successful aging in the Amish.
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DOI：
10.1007/s00439-011-1060-3
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发表时间：
2012-02
期刊：
影响因子：
5.3
通讯作者：
Scott WK
中科院分区：
文献类型：
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作者：
Courtenay MD;Gilbert JR;Jiang L;Cummings AC;Gallins PJ;Caywood L;Reinhart-Mercer L;Fuzzell D;Knebusch C;Laux R;McCauley JL;Jackson CE;Pericak-Vance MA;Haines JL;Scott WK
避免疾病，保持身体和认知功能，以及长寿个体的持续社会参与描述了成功的衰老（SA）。由常见遗传变异模式（“单倍型群”）描述的线粒体谱系与不同人群中的寿命增加有关。我们调查了线粒体单倍型群对SA在阿米什社区样本的影响。年龄≥80岁的认知功能完好的志愿者（n=261）参加了对印第安纳州和俄亥俄州阿米什人社区的挨家挨户调查。下肢功能得分在前三分之一的个体，几乎不需要自我护理任务的帮助，没有抑郁症状，并表示高生活满意度被认为是SA（n=74）。其余（n=187）作为对照。这些个体在一个13代系谱中来自51个母系。线粒体单倍型群分配使用10个线粒体单核苷酸多态性（mtSNPs）定义的9个最常见的欧洲单倍型群。还研究了来自全基因组关联小组的另外17个mtSNP。单倍型组，mtSNPs和SA之间的关联通过Logistic回归模型，通过广义估计方程，性别，年龄，体重指数和母系。SA病例携带单倍型X的可能性更大（OR=7.56，p=0.0015），携带单倍型J的可能性更小（OR=0.40，p=0.0003）。我们的研究结果代表了单倍群X与SA的新关联，并表明线粒体基因组中的变体可能促进老年人身体和认知功能的维持。
Avoiding disease, maintaining physical and cognitive function, and continued social engagement in long-lived individuals describe successful aging (SA). Mitochondrial lineages described by patterns of common genetic variants (“haplogroups”) have been associated with increased longevity in different populations. We investigated the influence of mitochondrial haplogroups on SA in an Amish community sample. Cognitively intact volunteers aged ≥80 (n=261) were enrolled in a door-to-door survey of Amish communities in Indiana and Ohio. Individuals scoring in the top third for lower extremity function, needing little assistance with self-care tasks, having no depression symptoms, and expressing high life satisfaction were considered SA (n=74). The remainder (n=187) were retained as controls. These individuals descend from 51 matrilines in a single 13 generation pedigree. Mitochondrial haplogroups were assigned using the 10 mitochondrial single nucleotide polymorphisms (mtSNPs) defining the nine most common European haplogroups. An additional 17 mtSNPs from a genome-wide association panel were also investigated. Associations between haplogroups, mtSNPs, and SA were determined by logistic regression models accounting for sex, age, body mass index, and matriline via generalized estimating equations. SA cases were more likely to carry Haplogroup X (OR=7.56, p=0.0015), and less likely to carry Haplogroup J (OR=0.40, p=0.0003). Our results represent a novel association of Haplogroup X with SA and suggest that variants in the mitochondrial genome may promote maintenance of both physical and cognitive function in older adults.