Parietal substrates for dimensional effects in visual search: evidence from lesion-symptom mapping
Parietal substrates for dimensional effects in visual search: evidence from lesion-symptom mapping
复制标题
视觉搜索中维度效应的顶叶基底：来自病变症状映射的证据
DOI：
10.1167/12.9.1146
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发表时间：
2012
影响因子：
1.8
通讯作者：
Utz S
中科院分区：
文献类型：
--
作者：
Utz S
在视觉搜索中，参与者被要求检测预定义目标的存在或不存在。在寻找突出式目标时，Müler，Heller和Ziegler(1995)发现，当目标定义维度与在不同试验中改变时(即较慢的反应时间)相比，目标定义维度保持不变时，促进了检测(即较快的反应时间[RTS])。我们测试了维度成本和收益的寿命，以寻找脑损伤患者的突出性目标，以进一步调查那些与遗留效应密切相关的区域。参与者必须搜索由其颜色(红色或蓝色)或方向(右倾斜或左倾斜)定义的目标。在连续的试验中，目标维度保持不变或改变。我们根据患者是否表现出维度变化对搜索的影响来对患者进行分类。使用基于体素的形态计量学(Asburner和Friston，2000)，我们比较了有维度效应的患者组(N=16)和没有维度效应的患者组(N=9)。在控制患者的空间缺陷(向左或向右；忽视加视觉消退)时，全脑体素分析显示，右侧顶下小叶(角回和缘上回，部分涉及顶内沟[IPS])内灰质的损害与维度降低相关(簇水平校正，p=0.0001)。Pollmann等人(2006)提出，当搜索发生维度变化时，几个核心解剖结构被激活，包括我们数据中发现的关键区域，他将这些区域与注意力从一个维度转移到另一个维度所涉及的过程联系起来。我们的数据表明，在视觉维度变化的背景下，顶叶皮质的这些区域对于注意力转移是必要的。
In visual search, participants are required to detect the presence or absence of a pre-defined target. In search for pop-out targets, Müller, Heller and Ziegler (1995) found facilitated detection (ie faster reaction times [RTs]) when the target defining dimension remained the same compared to when it changed across trials (ie slower RTs). We tested the longevity of dimensional costs and benefits in search for a pop-out target in patients who have suffered from brain damage to further investigate those areas critically involved in the carry-over effects. Participants had to search for targets defined by either its color (red or blue) or orientation (right-or left-tilted) dimension. On consecutive trials, the target dimension stayed the same or changed. We categorized patients according to whether they showed an effect of dimensional change on search or not. Using voxel-based morphometry (Asburner and Friston, 2000) we compared the group of patients with dimensional effects (N= 16) with the group of patients without dimensional effects (N= 9). While controlling for spatial deficits of the patients (either to left or right; neglect plus visual extinction), whole brain voxel-wise analysis showed that damage to grey matter within the right inferior parietal lobule (the angular and supramarginal gyri and partially involving the intraparietal sulcus [IPS]) was correlated with reduced dimensional effects (cluster level corrected, p= 0.0001). Pollmann et al.(2006) proposed that several core anatomical structures were activated when dimensional changes occur in search, including the regions found critical in our data, and he linked the regions to the processes involved in attention shifting from one dimension to another. Our data suggest that these regions of parietal cortex are necessary to attention shifting in the context of visual dimensional change.